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Mouse Anti-ZBTB49 Recombinant Antibody (3502C2a) (CBMAB-Z0100-WJ)

This product is a mouse antibody that recognizes ZBTB49. The antibody 3502C2a can be used for immunoassay techniques such as: Dot, WB.
See all ZBTB49 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3502C2a
Antibody Isotype
IgG1
Application
Dot, WB

Basic Information

Immunogen
Recombinant human Zinc Finger Protein 509.
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
0.1 mg/mL

Target

Full Name
Zinc Finger And BTB Domain Containing 49
Introduction
ZBTB49 (Zinc Finger And BTB Domain Containing 49) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and transcription factor binding. An important paralog of this gene is ZBTB17.
Entrez Gene ID
166793
UniProt ID
Q6ZSB9
Alternative Names
ZNF509
Function
Transcription factor. Inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription.
Isoform 1
Binds CDKN1A promoter and activates its transcription; this activity is further potentiated in the presence of EP300 (synergistic) and ZBTB17/Miz-1 (additive).
Isoform 3
Activates RB1 transcription most probably by antagonizing ZBTB17 repression of RB1. Does not bind directly RB1 promoter.
Biological Process
Biological Process cell cycle Source:UniProtKB-KW
Biological Process negative regulation of cell population proliferation Source:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase II Source:UniProtKB1 Publication
Biological Process regulation of cell cycle Source:UniProtKB1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Cellular Location
Isoform 1
Cytoplasm
Nucleus
Predominantly located in the nucleus.
Isoform 3
Cytoplasm
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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