ZFYVE20

This gene encodes a protein that belongs to the FYVE zinc finger family of proteins. The encoded protein interacts with Ras-related proteins that regulate membrane trafficking. A missense mutation in this gene is associated with a defect in the early endocytic pathway. Alternative splicing results in multiple transcript variants. Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3).

Full Name

ZFYVE20

Function

Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) (PubMed:11062261, PubMed:11788822, PubMed:15020713).
Plays a role in the recycling of transferrin receptor to the plasma membrane (PubMed:22308388).

Biological Process

Biological Process early endosome to Golgi transport Source:UniProtKB1 Publication
Biological Process endosomal transport Source:UniProtKB1 Publication
Biological Process Golgi to lysosome transport Source:UniProtKB1 Publication
Biological Process protein transport Source:UniProtKB-KW
Biological Process regulation of Golgi organization Source:UniProtKB1 Publication

Cellular Location

Cell membrane
Early endosome membrane
Enriched in endosomes that are in close proximity to clathrin-enriched regions at the cell surface.