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Rabbit Anti-CA9 Recombinant Antibody (036) (CBMAB-C1724-LY)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
036
Antibody Isotype
IgG
Application
E

Basic Information

Immunogen
Recombinant Human Carbonic Anhydrase IX / CA9 protein.
Host Species
Rabbit
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
ELISA1:5,000-1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
carbonic anhydrase 9
Entrez Gene ID
768
UniProt ID
Q16790
Function
Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia.
Biological Process
Bicarbonate transport Source: Reactome
Morphogenesis of an epithelium Source: Ensembl
One-carbon metabolic process Source: GO_Central
Regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: Reactome
Response to drug Source: Ensembl
Response to testosterone Source: Ensembl
Secretion Source: Ensembl
Cellular Location
Nucleus; Nucleolus; Cell membrane; Microvillus membrane. Found on the surface microvilli and in the nucleus, particularly in nucleolus.
Topology
Extracellular: 38-414 aa
Helical: 415-435 aa
Cytoplasmic: 436-459 aa
PTM
Asn-346 bears high-mannose type glycan structures.
More Infomation

Giatromanolaki, A., Harris, A. L., Banham, A. H., Contrafouris, C. A., & Koukourakis, M. I. (2020). Carbonic anhydrase 9 (CA9) expression in non-small-cell lung cancer: correlation with regulatory FOXP3+ T-cell tumour stroma infiltration. British journal of cancer, 122(8), 1205-1210.

Baniak, N., Flood, T. A., Buchanan, M., Dal Cin, P., & Hirsch, M. S. (2020). Carbonic anhydrase IX (CA9) expression in multiple renal epithelial tumour subtypes. Histopathology, 77(4), 659-666.

Wang, S., Fu, Z., Wang, Y., Sun, Y., Cui, L., Wang, C., ... & Wen, N. (2020). Correlation of carbonic anhydrase 9 (CA9) with pathological T-stage and prognosis in patients with oral tongue squamous cell carcinoma. Annals of Translational Medicine, 8(22).

Li, Z., Jiang, L., Chew, S. H., Hirayama, T., Sekido, Y., & Toyokuni, S. (2019). Carbonic anhydrase 9 confers resistance to ferroptosis/apoptosis in malignant mesothelioma under hypoxia. Redox biology, 26, 101297.

Eckert, A. W., Horter, S., Bethmann, D., Kotrba, J., Kaune, T., Rot, S., ... & Kappler, M. (2019). Investigation of the prognostic role of carbonic anhydrase 9 (CAIX) of the cellular mRNA/protein level or soluble CAIX protein in patients with oral squamous cell carcinoma. International journal of molecular sciences, 20(2), 375.

McDonald, P. C., Chafe, S. C., Brown, W. S., Saberi, S., Swayampakula, M., Venkateswaran, G., ... & Dedhar, S. (2019). Regulation of pH by carbonic anhydrase 9 mediates survival of pancreatic cancer cells with activated KRAS in response to hypoxia. Gastroenterology, 157(3), 823-837.

Finkelmeier, F., Canli, Ö., Peiffer, K. H., Walter, D., Tal, A., Koch, C., ... & Waidmann, O. (2018). Circulating hypoxia marker carbonic anhydrase IX (CA9) in patients with hepatocellular carcinoma and patients with cirrhosis. PloS one, 13(7), e0200855.

Kim, J. Y., Lee, S. H., An, S., Kim, S. J., Sung, Y. N., Song, K. B., ... & Hong, S. M. (2018). Carbonic anhydrase 9 expression in well-differentiated pancreatic neuroendocrine neoplasms might be associated with aggressive behavior and poor survival. Virchows Archiv, 472(5), 739-748.

Horie, K., Kawakami, K., Fujita, Y., Sugaya, M., Kameyama, K., Mizutani, K., ... & Ito, M. (2017). Exosomes expressing carbonic anhydrase 9 promote angiogenesis. Biochemical and biophysical research communications, 492(3), 356-361.

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For research use only. Not intended for any clinical use.

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