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CA9

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and is one of only two tumor-associated carbonic anhydrase isoenzymes known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12.
Full Name
carbonic anhydrase 9
Function
Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia.
Biological Process
Bicarbonate transport Source: Reactome
Morphogenesis of an epithelium Source: Ensembl
One-carbon metabolic process Source: GO_Central
Regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: Reactome
Response to drug Source: Ensembl
Response to testosterone Source: Ensembl
Secretion Source: Ensembl
Cellular Location
Nucleus; Nucleolus; Cell membrane; Microvillus membrane. Found on the surface microvilli and in the nucleus, particularly in nucleolus.
Topology
Extracellular: 38-414 aa
Helical: 415-435 aa
Cytoplasmic: 436-459 aa
PTM
Asn-346 bears high-mannose type glycan structures.
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Anti-CA9 antibodies

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Mouse Anti-CA9 Recombinant Antibody (CBXC-2079) (CBMAB-C0131-CQ)

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Target: CA9
Host: Mouse
Antibody Isotype: IgG2a, ĸ
Specificity: Human
Clone: CBXC-2079
Application*: E, WB, IF, IP, P
Datasheet SDS

Rabbit Anti-CA9 Monoclonal Antibody (EP161) (CBMAB-R0014-FY)

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Target: CA9
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EP161
Application*: E
Datasheet SDS

Mouse Anti-CA9 Recombinant Antibody (EC91) (V2LY-0624-LY91)

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Target: CA9
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: EC91
Application*: WB, P, IF
Datasheet SDS

Mouse Anti-CA9 Recombinant Antibody (326) (CBMAB-AP722LY)

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Target: CA9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 326
Application*: E
Datasheet SDS

Mouse Anti-CA9 Recombinant Antibody (CB384A) (CBMAB-CA384LY)

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Target: CA9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB384A
Application*: P
Datasheet SDS

Rabbit Anti-CA9 Recombinant Antibody (3) (CBMAB-C5423-LY)

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Target: CA9
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 3
Application*: FC
Datasheet SDS

Rabbit Anti-CA9 Recombinant Antibody (036) (CBMAB-C1724-LY)

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Target: CA9
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 036
Application*: E
Datasheet SDS

Rabbit Anti-CA9 Recombinant Antibody (005) (CBMAB-C1517-LY)

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Target: CA9
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 005
Application*: E, P
Datasheet SDS

Rabbit Anti-CA9 Recombinant Antibody (001) (CBMAB-C1442-LY)

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Target: CA9
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 001
Application*: P
Datasheet SDS

Mouse Anti-CA9 Recombinant Antibody (CBT4348) (V2LY-0625-LY63)

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Target: CA9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4348
Application*: WB, F
Datasheet SDS

Mouse Anti-CA9 Recombinant Antibody (CBT4395) (V2LY-0625-LY62)

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Target: CA9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4395
Application*: WB, IH
Datasheet SDS

Mouse Anti-CA9 Recombinant Antibody (CBT13) (V2LY-0625-LY3870)

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Target: CA9
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT13
Application*: IF, IC, WB, P, IP
Datasheet SDS

Mouse Anti-CA9 Recombinant Antibody (CBT248) (V2LY-0625-LY3668)

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Target: CA9
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT248
Application*: WB, P, IF, F, E
Datasheet SDS

Mouse Anti-CA9 Recombinant Antibody (CBT2582) (V2LY-0625-LY2582)

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Target: CA9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2582
Application*: WB, IH, F
Datasheet SDS

CA9 Matched Antibody Pair (165) (APMAB-165LY)

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Target: CA9
Specificity: Human
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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