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Rat Anti-CD101 Recombinant Antibody (CBYY-C0653) (CBMAB-C1944-YY)


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Published Data
CBMAB-C1944-YY-1
Rat Anti-CD101 Recombinant Antibody (CBYY-C0653) (CBMAB-C1944-YY) in FC
Lack of CD101 expression in CD101−/− NOD.B6 Idd10 and CD101−/− NOD.B6 Idd10/18 mice. CD11b-positive cells in the spleens of CD101−/− NOD.B6 Idd10 and CD101−/− NOD.B6 Idd10/18 mice as well as CD101-expressing control littermates were evaluated for their CD101-expression by flow cytometry. Representative FACS dot plots are displayed. ...View More
Mattner, J., Mohammed, J. P., Fusakio, M. E., Giessler, C., Hackstein, C. P., Opoka, R., ... & Wicker, L. S. (2019). Genetic and functional data identifying Cd101 as a type 1 diabetes (T1D) susceptibility gene in nonobese diabetic (NOD) mice. PLoS Genetics, 15(6), e1008178. Distributed under Open Access license CC BY 4.0, without modification.

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBYY-C0653
Antibody Isotype
IgG2a
Application
FC

Basic Information

Immunogen
Chinese hamster ovary cell line CHO-derived recombinant mouse IGSF2/CD101 Gln21-Tyr1033.
Host Species
Rat
Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
FC2.5 µg/10^6 cells

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Concentration
Lyophilized
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CD101 Molecule
Entrez Gene ID
630146
UniProt ID
A8E0Y8
Function
Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4+ CD56+ leukemic tumor cells.
Biological Process
Cell surface receptor signaling pathway Source: ProtInc
Positive regulation of myeloid leukocyte differentiation Source: Ensembl
Cellular Location
Membrane
Topology
Extracellular: 21-954
Helical: 955-975
Cytoplasmic: 976-1021
PTM
N-glycosylated.
More Infomation

Wrage, M., Kaltwasser, J., Menge, S., & Mattner, J. (2021). CD101 as an indicator molecule for pathological changes at the interface of host-microbiota interactions. International Journal of Medical Microbiology, 311(4), 151497.

Richert-Spuhler, L. E., Mar, C. M., Shinde, P., Wu, F., Hong, T., Greene, E., ... & Tappero, J. (2021). CD101 genetic variants modify regulatory and conventional T cell phenotypes and functions. Cell Reports Medicine, 2(6), 100322.

Zhu, C., Weng, Q. Y., Zhou, L. R., Cao, C., Li, F., Wu, Y. F., ... & Li, W. (2020). Homeostatic and early-recruited CD101− eosinophils suppress endotoxin-induced acute lung injury. European Respiratory Journal, 56(5).

Kong, Y. W., Feng, M. Q., & Sun, J. (2020). Effects of Lactobacillus plantarum CD101 and Staphylococcus simulans NJ201 on proteolytic changes and bioactivities (antioxidant and antihypertensive activities) in fermented pork sausage. LWT, 133, 109985.

Mattner, J., Mohammed, J. P., Fusakio, M. E., Giessler, C., Hackstein, C. P., Opoka, R., ... & Wicker, L. S. (2019). Genetic and functional data identifying Cd101 as a type 1 diabetes (T1D) susceptibility gene in nonobese diabetic (NOD) mice. PLoS genetics, 15(6), e1008178.

Berkow, E. L., & Lockhart, S. R. (2018). Activity of CD101, a long-acting echinocandin, against clinical isolates of Candida auris. Diagnostic microbiology and infectious disease, 90(3), 196-197.

Mackelprang, R. D., Bamshad, M. J., Chong, J. X., Hou, X., Buckingham, K. J., Shively, K., ... & Partners in Prevention HSV/HIV Transmission Study and the Partners PrEP Study Teams. (2017). Whole genome sequencing of extreme phenotypes identifies variants in CD101 and UBE2V1 associated with increased risk of sexually acquired HIV-1. PLoS pathogens, 13(11), e1006703.

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For research use only. Not intended for any clinical use.

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