CD101
CD101 (CD101 Molecule) is a Protein Coding gene. Diseases associated with CD101 include Langerhans Cell Histiocytosis and Histiocytosis. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides. An important paralog of this gene is IGSF3.
Full Name
CD101 Molecule
Function
Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4+ CD56+ leukemic tumor cells.
Biological Process
Cell surface receptor signaling pathway Source: ProtInc
Positive regulation of myeloid leukocyte differentiation Source: Ensembl
Positive regulation of myeloid leukocyte differentiation Source: Ensembl
Cellular Location
Membrane
Topology
Extracellular: 21-954
Helical: 955-975
Cytoplasmic: 976-1021
Helical: 955-975
Cytoplasmic: 976-1021
PTM
N-glycosylated.
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Anti-CD101 antibodies
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Target: CD101
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: BB27
Application*: F, IP, IH
Target: CD101
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2885
Application*: WB
Target: CD101
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3446
Application*: F
Target: CD101
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2749
Application*: WB, E
Target: CD101
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYY-C0653
Application*: F
Target: CD101
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0852
Application*: WB, E, F
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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