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Mouse Anti-CD101 Recombinant Antibody (BB27) (CBMAB-AP928LY)


See all CD101 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
BB27
Antibody Isotype
IgG1
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CD101 Molecule
Introduction
CD101 (CD101 Molecule) is a Protein Coding gene. Diseases associated with CD101 include Langerhans Cell Histiocytosis and Histiocytosis. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides. An important paralog of this gene is IGSF3.
Entrez Gene ID
9398
UniProt ID
Q93033
Alternative Names
CD101 Molecule; Glu-Trp-Ile EWI Motif-Containing Protein 101; Cell Surface Glycoprotein V7; EWI-101; IGSF2; V7;
Function
Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4+ CD56+ leukemic tumor cells.
Biological Process
Cell surface receptor signaling pathway Source: ProtInc
Positive regulation of myeloid leukocyte differentiation Source: Ensembl
Cellular Location
Membrane
Topology
Extracellular: 21-954
Helical: 955-975
Cytoplasmic: 976-1021
PTM
N-glycosylated.

Wrage, M., Kaltwasser, J., Menge, S., & Mattner, J. (2021). CD101 as an indicator molecule for pathological changes at the interface of host-microbiota interactions. International Journal of Medical Microbiology, 311(4), 151497.

Richert-Spuhler, L. E., Mar, C. M., Shinde, P., Wu, F., Hong, T., Greene, E., ... & Tappero, J. (2021). CD101 genetic variants modify regulatory and conventional T cell phenotypes and functions. Cell Reports Medicine, 2(6), 100322.

Zhu, C., Weng, Q. Y., Zhou, L. R., Cao, C., Li, F., Wu, Y. F., ... & Li, W. (2020). Homeostatic and early-recruited CD101− eosinophils suppress endotoxin-induced acute lung injury. European Respiratory Journal, 56(5).

Kong, Y. W., Feng, M. Q., & Sun, J. (2020). Effects of Lactobacillus plantarum CD101 and Staphylococcus simulans NJ201 on proteolytic changes and bioactivities (antioxidant and antihypertensive activities) in fermented pork sausage. LWT, 133, 109985.

Mattner, J., Mohammed, J. P., Fusakio, M. E., Giessler, C., Hackstein, C. P., Opoka, R., ... & Wicker, L. S. (2019). Genetic and functional data identifying Cd101 as a type 1 diabetes (T1D) susceptibility gene in nonobese diabetic (NOD) mice. PLoS genetics, 15(6), e1008178.

Berkow, E. L., & Lockhart, S. R. (2018). Activity of CD101, a long-acting echinocandin, against clinical isolates of Candida auris. Diagnostic microbiology and infectious disease, 90(3), 196-197.

Mackelprang, R. D., Bamshad, M. J., Chong, J. X., Hou, X., Buckingham, K. J., Shively, K., ... & Partners in Prevention HSV/HIV Transmission Study and the Partners PrEP Study Teams. (2017). Whole genome sequencing of extreme phenotypes identifies variants in CD101 and UBE2V1 associated with increased risk of sexually acquired HIV-1. PLoS pathogens, 13(11), e1006703.

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For research use only. Not intended for any clinical use.

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