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Mouse Anti-DNAJC3 Recombinant Antibody (4D3-F2) (V2LY-0425-LY655)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
4D3-F2
Antibody Isotype
IgG2a, κ
Application
ELISA, WB, IF

Basic Information

Immunogen
Full-length recombinant DNAJC27.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
IF(ICC)10 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
DnaJ Heat Shock Protein Family (Hsp40) Member C3
Entrez Gene ID
Human5611
Mouse100037258
UniProt ID
HumanQ13217
MouseQ91YW3
Function
Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity).

Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity.
Biological Process
Cellular response to cold Source: UniProtKB
Defense response to virus Source: UniProtKB-KW
Negative regulation of apoptotic process Source: ParkinsonsUK-UCL
Negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation Source: ParkinsonsUK-UCL
Positive regulation of translation initiation in response to endoplasmic reticulum stress Source: UniProtKB
Protein folding in endoplasmic reticulum Source: GO_Central
Proteolysis involved in cellular protein catabolic process Source: Ensembl
Response to unfolded protein Source: UniProtKB-KW
Cellular Location
Endoplasmic reticulum
Involvement in disease
Ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus (ACPHD):
A disease characterized by juvenile-onset diabetes and neurodegeneration, resulting in ataxia, upper-motor-neuron damage, peripheral neuropathy, hearing loss, and cerebral atrophy.
More Infomation

Li, H., Bi, K., Feng, S., Wang, Y., & Zhu, C. (2022). MiR-140 targets lncRNA DNAJC3-AS1 to suppress cell proliferation in acute myeloid leukemia. Mediterranean Journal of Hematology and Infectious Diseases, 14(1).

Lytrivi, M., Senée, V., Salpea, P., Fantuzzi, F., Philippi, A., Abdulkarim, B., ... & Cnop, M. (2021). DNAJC3 deficiency induces β-cell mitochondrial apoptosis and causes syndromic young-onset diabetes. European journal of endocrinology, 184(3), 459-472.

Tang, Y., Tang, R., Tang, M., Huang, P., Liao, Z., Zhou, J., ... & Nie, S. (2021). LncRNA DNAJC3-AS1 regulates fatty acid synthase via the EGFR pathway to promote the progression of colorectal cancer. Frontiers in oncology, 10, 3272.

Na, X. Y., Hu, X. Q., Zhao, Y., Hu, C. H., & Shang, X. S. (2021). LncRNA DNAJC3-AS1 functions as oncogene in renal cell carcinoma via regulation of the miR-27a-3p/PRDM14 axis. Eur Rev Med Pharmacol Sci, 25(3), 1291-1301.

Jennings, M. J., Hathazi, D., Nguyen, C. D., Munro, B., Münchberg, U., Ahrends, R., ... & Roos, A. (2021). Intracellular Lipid Accumulation and Mitochondrial Dysfunction Accompanies Endoplasmic Reticulum Stress Caused by Loss of the Co-chaperone DNAJC3. Frontiers in Cell and Developmental Biology, 9.

Fu, C., Li, J., Li, P., & Cheng, D. (2021). LncRNA DNAJC3-AS1 Promotes Hepatocellular Carcinoma (HCC) progression via sponging premature miR-27b. Cancer Management and Research, 13, 8575.

Han, B., Ge, Y., Cui, J., & Liu, B. (2020). Down-regulation of lncRNA DNAJC3-AS1 inhibits colon cancer via regulating miR-214-3p/LIVIN axis. Bioengineered, 11(1), 524-535.

Ozon, Z. A., Alikasifoglu, A., Kandemir, N., Aydin, B., Gonc, E. N., Karaosmanoglu, B., ... & Alikasifoglu, M. (2020). Novel insights into diabetes mellitus due to DNAJC3‐defect: Evolution of neurological and endocrine phenotype in the pediatric age group. Pediatric diabetes, 21(7), 1176-1182.

Liang, R., Liu, Z., Chen, Z., Yang, Y., Li, Y., Cui, Z., ... & Li, Q. (2019). Long noncoding RNA DNAJC3‐AS1 promotes osteosarcoma progression via its sense‐cognate gene DNAJC3. Cancer medicine, 8(2), 761-772.

Zhang, X., Li, G., Yang, X., Wang, L., Wang, Y., Guo, X., ... & Xu, B. (2019). Identification of a DnaJC3 gene in Apis cerana cerana and its involvement in various stress responses. Pesticide biochemistry and physiology, 160, 171-180.

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For research use only. Not intended for any clinical use.

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