DNAJC3

This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR). [provided by RefSeq, Jul 2010]
Full Name
DnaJ Heat Shock Protein Family (Hsp40) Member C3
Function
Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity).

Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity.
Biological Process
Cellular response to cold Source: UniProtKB
Defense response to virus Source: UniProtKB-KW
Negative regulation of apoptotic process Source: ParkinsonsUK-UCL
Negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation Source: ParkinsonsUK-UCL
Positive regulation of translation initiation in response to endoplasmic reticulum stress Source: UniProtKB
Protein folding in endoplasmic reticulum Source: GO_Central
Proteolysis involved in cellular protein catabolic process Source: Ensembl
Response to unfolded protein Source: UniProtKB-KW
Cellular Location
Endoplasmic reticulum
Involvement in disease
Ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus (ACPHD):
A disease characterized by juvenile-onset diabetes and neurodegeneration, resulting in ataxia, upper-motor-neuron damage, peripheral neuropathy, hearing loss, and cerebral atrophy.
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Anti-DNAJC3 antibodies

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Rabbit Anti-DNAJC3 Recombinant Antibody (P0281) (V2LY-0425-LY658)

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Target: DNAJC3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Monkey
Clone: P0281
Application*: WB
Datasheet SDS

Mouse Anti-DNAJC3 Recombinant Antibody (D1318) (V2LY-0425-LY657)

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Target: DNAJC3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: D1318
Application*: E, WB, IF
Datasheet SDS

Mouse Anti-DNAJC3 Recombinant Antibody (CBYCD-345) (V2LY-0425-LY656)

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Target: DNAJC3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYCD-345
Application*: WB, IP, IF, E, P
Datasheet SDS

Mouse Anti-DNAJC3 Recombinant Antibody (4D3-F2) (V2LY-0425-LY655)

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Target: DNAJC3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: 4D3-F2
Application*: E, WB, IF
Datasheet SDS

Rabbit Anti-DNAJC3 Recombinant Antibody (C56E7) (CBMAB-P0281-YC)

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Target: DNAJC3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Monkey
Clone: C56E7
Application*: WB, IP
Datasheet SDS

Rabbit Anti-DNAJC3 Recombinant Antibody (J.98.6) (CBMAB-D1318-YC)

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Target: DNAJC3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: J.98.6
Application*: IP, WB
Datasheet SDS

Mouse Anti-DNAJC3 Recombinant Antibody (CBYCD-345) (CBMAB-D1316-YC)

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Target: DNAJC3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYCD-345
Application*: WB, IC, IF
Datasheet SDS

Mouse Anti-DNAJC3 Recombinant Antibody (4D3-F2) (CBMAB-D1315-YC)

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Target: DNAJC3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4D3-F2
Application*: IF
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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