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Mouse Anti-DUSP9 Recombinant Antibody (CBFYM-1080) (CBMAB-M1234-FY)

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
CBFYM-1080
Application
WB, IP, IF, ELISA, IHC-P
Immunogen
Amino acids 340-384 mapping at the C-terminus of human MKP-4.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
ELISA1:100-1:1,000
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
IHC-P1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Gelatin & PBS
Preservative
Sodium Azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Dual Specificity Phosphatase 9
Introduction
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases and is localized to the cytoplasm and nucleus. Aberrant expression of this gene is associated with type 2 diabetes and cancer progression in several cell types. Alternate splicing results in multiple transcript variants.
Entrez Gene ID
Human1852
Mouse75590
Rat293847
UniProt ID
HumanQ99956
MouseQ7TNL7
RatQ2YDV1
Alternative Names
Dual Specificity Phosphatase 9; Map Kinase Phosphatase 4; Mitogen-Activated Protein Kinase Phosphatase 4; MKP-4; MKP4; Serine/Threonine Specific Protein Phosphatase; Dual Specificity Protein Phosphatase 9; EC 3.1.3.16; EC 3.1.3.48
Research Area
Inactivates MAP kinases. Has a specificity for the ERK family.
Biological Process
Activation of MAPK activity Source: Reactome
Inactivation of MAPK activity Source: GO_Central
JNK cascade Source: ProtInc
MAPK cascade Source: Reactome
Negative regulation of ERK1 and ERK2 cascade Source: GO_Central
Peptidyl-threonine dephosphorylation Source: GO_Central
Peptidyl-tyrosine dephosphorylation Source: GO_Central
Positive regulation of apoptotic process Source: GO_Central
Protein dephosphorylation Source: GO_Central
Regulation of heart growth Source: GO_Central
Cellular Location
Cytoplasm

Khoubai, F. Z., & Grosset, C. F. (2021). DUSP9, a Dual-Specificity Phosphatase with a Key Role in Cell Biology and Human Diseases. International Journal of Molecular Sciences, 22(21), 11538.

Chen, K., Gorgen, A., Ding, A., Du, L., Jiang, K., Ding, Y., ... & Ghanekar, A. (2021). Dual‐Specificity Phosphatase 9 Regulates Cellular Proliferation and Predicts Recurrence after Surgery in Hepatocellular Carcinoma. Hepatology communications, 5(7), 1310-1328.

Jiang, L., Ren, L., Guo, X., Zhao, J., Zhang, H., Chen, S., ... & Xia, J. (2021). Dual-specificity phosphatase 9 protects against cardiac hypertrophy by targeting ASK1. International Journal of Biological Sciences, 17(9), 2193.

Acharya, S., Dutta, S., Mudrale, S. P., & Bose, K. (2020). Dual specificity phosphatase 9: A novel binding partner cum substrate of proapoptotic serine protease HtrA2. Biochemical and Biophysical Research Communications, 533(3), 607-612.

Ye, P., Xiang, M., Liao, H., Liu, J., Luo, H., Wang, Y., ... & Xia, J. (2019). Dual‐specificity phosphatase 9 Protects against nonalcoholic fatty liver disease in mice through ASK1 suppression. Hepatology, 69(1), 76-93.

Wei, Q., Pu, X., Zhang, L., Xu, Y., Duan, M., & Wang, Y. (2019). Expression of dual-specificity phosphatase 9 in placenta and its relationship with gestational diabetes mellitus. Journal of Diabetes Research, 2019.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

DUSP9 Matched Antibody Pair (354) (CAT#: APMAB-354LY)

Related Products

Mouse Anti-DUSP9 Recombinant Antibody (2E3) (CAT#: CBMAB-D1919-YC)

DUSP9 Matched Antibody Pair (354) (CAT#: APMAB-354LY)

Rabbit Anti-DUSP9 Recombinant Antibody (EG1008) (CAT#: V2LY-0425-LY1099)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Request bulk or custom quote Second antibody and isotype control

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