Mouse Anti-DUSP9 Recombinant Antibody (2E3) (CBMAB-D1919-YC)

Name: Mouse Anti-DUSP9 Recombinant Antibody (2E3)
SKU: CBMAB-D1919-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2E3

Application

ELISA, PLA, WB

Immunogen

DUSP9 (aa174-278) partial recombinant protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 174-278

More Infomation

Target

Full Name

Dual Specificity Phosphatase 9

Introduction

DUSP9 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases and is localized to the cytoplasm and nucleus. Aberrant expression of this gene is associated with type 2 diabetes and cancer progression in several cell types.

Entrez Gene ID

1852

UniProt ID

Q99956

Alternative Names

Dual Specificity Phosphatase 9; Map Kinase Phosphatase 4; Mitogen-Activated Protein Kinase Phosphatase 4; MKP-4; MKP4; Serine/Threonine Specific Protein Phosphatase; Dual Specificity Protein Phosphatase 9; EC 3.1.3.16; EC 3.1.3.48;

Research Area

Inactivates MAP kinases. Has a specificity for the ERK family.

Biological Process

Activation of MAPK activity Source: Reactome
Inactivation of MAPK activity Source: GO_Central
JNK cascade Source: ProtInc
MAPK cascade Source: Reactome
Negative regulation of ERK1 and ERK2 cascade Source: GO_Central
Peptidyl-threonine dephosphorylation Source: GO_Central
Peptidyl-tyrosine dephosphorylation Source: GO_Central
Positive regulation of apoptotic process Source: GO_Central
Protein dephosphorylation Source: GO_Central
Regulation of heart growth Source: GO_Central

Cellular Location

Cytoplasm

Khoubai, F. Z., & Grosset, C. F. (2021). DUSP9, a Dual-Specificity Phosphatase with a Key Role in Cell Biology and Human Diseases. International Journal of Molecular Sciences, 22(21), 11538.

Chen, K., Gorgen, A., Ding, A., Du, L., Jiang, K., Ding, Y., ... & Ghanekar, A. (2021). Dual‐Specificity Phosphatase 9 Regulates Cellular Proliferation and Predicts Recurrence after Surgery in Hepatocellular Carcinoma. Hepatology communications, 5(7), 1310-1328.

Jiang, L., Ren, L., Guo, X., Zhao, J., Zhang, H., Chen, S., ... & Xia, J. (2021). Dual-specificity phosphatase 9 protects against cardiac hypertrophy by targeting ASK1. International Journal of Biological Sciences, 17(9), 2193.

Acharya, S., Dutta, S., Mudrale, S. P., & Bose, K. (2020). Dual specificity phosphatase 9: A novel binding partner cum substrate of proapoptotic serine protease HtrA2. Biochemical and Biophysical Research Communications, 533(3), 607-612.

Ye, P., Xiang, M., Liao, H., Liu, J., Luo, H., Wang, Y., ... & Xia, J. (2019). Dual‐specificity phosphatase 9 Protects against nonalcoholic fatty liver disease in mice through ASK1 suppression. Hepatology, 69(1), 76-93.

Wei, Q., Pu, X., Zhang, L., Xu, Y., Duan, M., & Wang, Y. (2019). Expression of dual-specificity phosphatase 9 in placenta and its relationship with gestational diabetes mellitus. Journal of Diabetes Research, 2019.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

DUSP9 Matched Antibody Pair (354) (CAT#: APMAB-354LY)

Related Products

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DUSP9 Matched Antibody Pair (354) (CAT#: APMAB-354LY)

Mouse Anti-DUSP9 Recombinant Antibody (CBFYM-1080) (CAT#: CBMAB-M1234-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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