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Mouse Anti-DUSP9 Recombinant Antibody (2E3) (CBMAB-D1919-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Dual Specificity Phosphatase 9 (DUSP9). The antibody can be used for immunoassay techniques, such as ELISA, PLA, WB.
See all DUSP9 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2E3
Antibody Isotype
IgG2a, κ
Application
ELISA, PLA, WB

Basic Information

Immunogen
DUSP9 (NP_001386, 174 a.a. ~ 278 a.a) partial recombinant protein with GST tag. The immunogen sequence: AESEADRDSM SCGLDSEGAT PPPVGLRASF PVQILPNLYL GSARDSANLE SLAKLGIRYI LNVTPNLPNF FEKNGDFHYK QIPISDHWSQ NLSRFFPEAI EFIDE
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 174-278

Target

Full Name
Dual Specificity Phosphatase 9
Introduction
DUSP9 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases and is localized to the cytoplasm and nucleus. Aberrant expression of this gene is associated with type 2 diabetes and cancer progression in several cell types.
Entrez Gene ID
1852
UniProt ID
Q99956
Alternative Names
Dual Specificity Phosphatase 9; Map Kinase Phosphatase 4; Mitogen-Activated Protein Kinase Phosphatase 4; MKP-4; MKP4; Serine/Threonine Specific Protein Phosphatase; Dual Specificity Protein Phosphatase 9; EC 3.1.3.16; EC 3.1.3.48;
Research Area
Inactivates MAP kinases. Has a specificity for the ERK family.
Biological Process
Activation of MAPK activity Source: Reactome
Inactivation of MAPK activity Source: GO_Central
JNK cascade Source: ProtInc
MAPK cascade Source: Reactome
Negative regulation of ERK1 and ERK2 cascade Source: GO_Central
Peptidyl-threonine dephosphorylation Source: GO_Central
Peptidyl-tyrosine dephosphorylation Source: GO_Central
Positive regulation of apoptotic process Source: GO_Central
Protein dephosphorylation Source: GO_Central
Regulation of heart growth Source: GO_Central
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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