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Rabbit Anti-DYRK1A Recombinant Antibody (EG1014) (CBMAB-EN1197-LY)

The product is antibody recognizes DYR1A. The antibody EG1014 immunoassay techniques such as: WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:1000.
See all DYRK1A antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EG1014
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:1000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human DYR1A.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A
Entrez Gene ID
Human1859
Mouse13548
Rat25255
UniProt ID
HumanQ13627
MouseQ61214
RatQ63470
Research Area
Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity).

Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (By similarity).
Biological Process
Amyloid-beta formation Source: ARUK-UCL
Circadian rhythm Source: UniProtKB
Negative regulation of DNA damage response, signal transduction by p53 class mediator Source: BHF-UCL
Negative regulation of microtubule polymerization Source: ARUK-UCL
Negative regulation of mRNA splicing, via spliceosome Source: Ensembl
Nervous system development Source: ProtInc
Peptidyl-serine autophosphorylation Source: ARUK-UCL
Peptidyl-serine phosphorylation Source: ARUK-UCL
Peptidyl-threonine phosphorylation Source: BHF-UCL
Peptidyl-tyrosine autophosphorylation Source: ARUK-UCL
Peptidyl-tyrosine phosphorylation Source: MGI
Positive regulation of protein deacetylation Source: BHF-UCL
Positive regulation of RNA splicing Source: ARUK-UCL
Positive regulation of transcription, DNA-templated Source: GO_Central
Protein autophosphorylation Source: UniProtKB
Protein phosphorylation Source: UniProtKB
Regulation of alternative mRNA splicing, via spliceosome Source: Ensembl
Cellular Location
Nucleus; Nucleus speckle
Involvement in disease
Mental retardation, autosomal dominant 7 (MRD7):
A disease characterized by primary microcephaly, severe mental retardation without speech, anxious autistic behavior, and dysmorphic features, including bitemporal narrowing, deep-set eyes, large simple ears, and a pointed nasal tip. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
PTM
Autophosphorylated on numerous tyrosine residues. Can also autophosphorylate on serine and threonine residues (in vitro).

Bessone, I. F., Navarro, J., Martinez, E., Karmirian, K., Holubiec, M., Alloatti, M., ... & Falzone, T. L. (2022). DYRK1A regulates the bidirectional axonal transport of APP in human-derived neurons. Journal of Neuroscience, 42(33), 6344-6358.

Weber, C., Sipos, M., Paczal, A., Balint, B., Kun, V., Foloppe, N., ... & Kotschy, A. (2021). Structure-guided discovery of potent and selective DYRK1A inhibitors. Journal of Medicinal Chemistry, 64(10), 6745-6764.

Demuro, S., Di Martino, R. M., Ortega, J. A., & Cavalli, A. (2021). GSK-3β, FYN, and DYRK1A: master regulators in neurodegenerative pathways. International Journal of Molecular Sciences, 22(16), 9098.

Laham, A. J., Saber-Ayad, M., & El-Awady, R. (2021). DYRK1A: A down syndrome-related dual protein kinase with a versatile role in tumorigenesis. Cellular and Molecular Life Sciences, 78(2), 603-619.

Bhansali, R. S., Rammohan, M., Lee, P., Laurent, A. P., Wen, Q., Suraneni, P., ... & Crispino, J. D. (2021). DYRK1A regulates B cell acute lymphoblastic leukemia through phosphorylation of FOXO1 and STAT3. The Journal of clinical investigation, 131(1).

Lee Walmsley, D., Murray, J. B., Dokurno, P., Massey, A. J., Benwell, K., Fiumana, A., ... & Hubbard, R. E. (2021). Fragment-derived selective inhibitors of dual-specificity kinases DYRK1A and DYRK1B. Journal of Medicinal Chemistry, 64(13), 8971-8991.

Walter, C., Marada, A., Suhm, T., Ernsberger, R., Muders, V., Kücükköse, C., ... & Meisinger, C. (2021). Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery. Nature communications, 12(1), 1-12.

Kumar, K., Suebsuwong, C., Wang, P., Garcia-Ocana, A., Stewart, A. F., & DeVita, R. J. (2021). DYRK1A inhibitors as potential therapeutics for β-cell regeneration for diabetes. Journal of Medicinal Chemistry, 64(6), 2901-2922.

Recasens, A., Humphrey, S. J., Ellis, M., Hoque, M., Abbassi, R. H., Chen, B., ... & Munoz, L. (2021). Global phosphoproteomics reveals DYRK1A regulates CDK1 activity in glioblastoma cells. Cell death discovery, 7(1), 1-16.

Arbones, M. L., Thomazeau, A., Nakano-Kobayashi, A., Hagiwara, M., & Delabar, J. M. (2019). DYRK1A and cognition: A lifelong relationship. Pharmacology & therapeutics, 194, 199-221.

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For research use only. Not intended for any clinical use.

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