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Mouse Anti-EBF3 Recombinant Antibody (CBFYE-0013) (CBMAB-E0026-FY)

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Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
CBFYE-0013
Application
ELISA, IHC, WB
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
early B-cell factor 3
Introduction
This gene encodes a member of the early B-cell factor (EBF) family of DNA binding transcription factors. EBF proteins are involved in B-cell differentiation, bone development and neurogenesis, and may also function as tumor suppressors. The encoded protein inhibits cell survival through the regulation of genes involved in cell cycle arrest and apoptosis, and aberrant methylation or deletion of this gene may play a role in multiple malignancies including glioblastoma multiforme and gastric carcinoma.
Entrez Gene ID
253738
UniProt ID
Q9H4W6
Alternative Names
Early B Cell Factor 3; Early B-Cell Factor 3; Olf-1/EBF-Like 2; EBF-3; O/E-2; COE3; OE-2; Transcription Factor COE3; HADDS
Research Area
Transcriptional activator (PubMed:28017373, PubMed:28017372, PubMed:28017370).

Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity).
Biological Process
Positive regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
Hypotonia, ataxia, and delayed development syndrome (HADDS):
An autosomal dominant neurodevelopmental syndrome characterized by global developmental delay, moderate to severe intellectual disability, cerebellar ataxia, hypotonia, speech delay, variable dysmorphic features, and genitourinary abnormalities including vesicoureteric reflux.

Deisseroth, C. A., Lerma, V. C., Magyar, C. L., Pfliger, J. M., Nayak, A., Bliss, N. D., ... & Chao, H. T. (2022). An Integrated Phenotypic and Genotypic Approach Reveals a High‐Risk Subtype Association for EBF3 Missense Variants Affecting the Zinc Finger Domain. Annals of Neurology.

Ding, S., Wang, X., Lv, D., Tao, Y., Liu, S., Chen, C., ... & Xia, Y. (2022). EBF3 reactivation by inhibiting the EGR1/EZH2/HDAC9 complex promotes metastasis via transcriptionally enhancing vimentin in nasopharyngeal carcinoma. Cancer Letters, 527, 49-65.

Ignatius, E., Puosi, R., Palomäki, M., Forsbom, N., Pohjanpelto, M., Alitalo, T., ... & Isohanni, P. (2022). Duplication/triplication mosaicism of EBF3 and expansion of the EBF3 neurodevelopmental disorder phenotype. European Journal of Paediatric Neurology, 37, 1-7.

de la Peña, M. J., de Domingo, A. J., Tirado, P., Calleja-Pérez, B., Alcaraz, L. A., Álvarez, S., ... & Fernández-Jaén, A. (2021). Neuroimaging findings in patients with EBF3 mutations: report of two cases. Molecular Syndromology, 12(3), 186-193.

Kuriki, M., Sato, F., Arai, H. N., Sogabe, M., Kaneko, M., Kiyonari, H., ... & Sehara-Fujisawa, A. (2020). Transient and lineage-restricted requirement of Ebf3 for sternum ossification. Development, 147(9), d

Iwai, R., Tabata, H., Inoue, M., Nomura, K. I., Okamoto, T., Ichihashi, M., ... & Mizutani, K. I. (2018). A Prdm8 target gene Ebf3 regulates multipolar-to-bipolar transition in migrating neocortical cells. Biochemical and biophysical research communications, 495(1), 388-394.

Seike, M., Omatsu, Y., Watanabe, H., Kondoh, G., & Nagasawa, T. (2018). Stem cell niche-specific Ebf3 maintains the bone marrow cavity. Genes & Development, 32(5-6), 359-372.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Alternative Versions

Mouse Anti-EBF3 Recombinant Antibody (CBFYE-0013) (CAT#: V2LY-0425-LY1279)

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Mouse Anti-EBF3 Recombinant Antibody (CBFYE-0013) (CAT#: V2LY-0425-LY1279)

Mouse Anti-EBF3 Recombinant Antibody (8D6) (CAT#: CBMAB-A2426-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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