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EBF3

This gene encodes a member of the early B-cell factor (EBF) family of DNA binding transcription factors. EBF proteins are involved in B-cell differentiation, bone development and neurogenesis, and may also function as tumor suppressors. The encoded protein inhibits cell survival through the regulation of genes involved in cell cycle arrest and apoptosis, and aberrant methylation or deletion of this gene may play a role in multiple malignancies including glioblastoma multiforme and gastric carcinoma.
Full Name
early B-cell factor 3
Research Area
Transcriptional activator (PubMed:28017373, PubMed:28017372, PubMed:28017370).

Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity).
Biological Process
Positive regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
Hypotonia, ataxia, and delayed development syndrome (HADDS):
An autosomal dominant neurodevelopmental syndrome characterized by global developmental delay, moderate to severe intellectual disability, cerebellar ataxia, hypotonia, speech delay, variable dysmorphic features, and genitourinary abnormalities including vesicoureteric reflux.
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Anti-EBF3 antibodies

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Mouse Anti-EBF3 Recombinant Antibody (8D6) (CBMAB-A2426-LY)

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Target: EBF3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat
Clone: 8D6
Application*: WB, E
Datasheet SDS

Mouse Anti-EBF3 Recombinant Antibody (CBFYE-0013) (CBMAB-E0026-FY)

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Target: EBF3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYE-0013
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-EBF3 Recombinant Antibody (8D6) (V2LY-0425-LY1280)

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Target: EBF3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: 8D6
Application*: WB, E, P
Datasheet SDS

Mouse Anti-EBF3 Recombinant Antibody (CBFYE-0013) (V2LY-0425-LY1279)

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Target: EBF3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat
Clone: CBFYE-0013
Application*: WB, E
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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