Mouse Anti-ELAVL3 Recombinant Antibody (16A11) (CBMAB-1351-YC)

Name: Mouse Anti-ELAVL3 Recombinant Antibody (16A11)
SKU: CBMAB-1351-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

16A11

Application

WB, IP, IF, ELISA

Immunogen

Amino acids 265-287 within an internal region of human HuC.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
ELISA	1:100-1:1,000
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, gelatin

Preservative

Sodium azide

Concentration

0.2 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Elav Like Rna Binding Protein 3

Introduction

ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. ELAVL3 is one of several Hu antigens recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis.

Entrez Gene ID

Human	1995
Pig	100515074
Rat	282824

UniProt ID

Human	Q14576
Pig	F1SA16
Rat	Q76IJ9

Alternative Names

HUC; HUCL; PLE21

Research Area

RNA-binding protein that binds to AU-rich element (ARE) sequences of target mRNAs, including VEGF mRNA (PubMed:10710437).

May also bind poly-A tracts via RRM 3 (By similarity).

May be involved in neuronal differentiation and maintenance (By similarity).

Plays a role in the stabilization of GAP43 mRNA and in spatial learning (By similarity).

Biological Process

Cell differentiation Source: UniProtKB-KW
Nervous system development Source: UniProtKB-KW

Cellular Location

Ribonucleoprotein complex

Lu, Y. L., Liu, Y., McCoy, M. J., & Yoo, A. S. (2021). MiR-124 synergism with ELAVL3 enhances target gene expression to promote neuronal maturity. Proceedings of the National Academy of Sciences, 118(22), e2015454118.

Diaz-Garcia, S., Ko, V. I., Vazquez-Sanchez, S., Chia, R., Arogundade, O. A., Rodriguez, M. J., ... & Ravits, J. (2021). Nuclear depletion of RNA-binding protein ELAVL3 (HuC) in sporadic and familial amyotrophic lateral sclerosis. Acta neuropathologica, 142(6), 985-1001.

Grassi, E., Santoro, R., Umbach, A., Grosso, A., Oliviero, S., Neri, F., ... & Merlo, G. R. (2019). Choice of alternative polyadenylation sites, mediated by the RNA-binding protein Elavl3, plays a role in differentiation of inhibitory neuronal progenitors. Frontiers in cellular neuroscience, 12, 518.

Ogawa, Y., Yamaguchi, J., Yano, M., Uchiyama, Y., & Okano, H. J. (2018). Elavl3 regulates neuronal polarity through the alternative splicing of an embryo-specific exon in AnkyrinG. Neuroscience Research, 135, 13-20.

Ogawa, Y., Kakumoto, K., Yoshida, T., Kuwako, K. I., Miyazaki, T., Yamaguchi, J., ... & Okano, H. J. (2018). Elavl3 is essential for the maintenance of Purkinje neuron axons. Scientific reports, 8(1), 1-13.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Mouse Anti-ELAVL3 Recombinant Antibody (CBFYE-0764) (CAT#: V2LY-0825-LY46)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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