Mouse Anti-ELAVL3 Monoclonal Antibody (16A11) (CBMAB-1351-YC)

Provided herein is a mouse monoclonal antibody against Human ELAVL3. The antibody, clone 16A11, can be used for immunoassay techniques, such as IF, IHC, IHC-Fr and WB.
See all ELAVL3 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Rat, Pig, Chicken, Zebrafish

Clone

16A11

Antibody Isotype

IgG2b, κ

Application

IF, IHC, IHC-Fr, WB

Basic Information

Immunogen

Human HuC/HuD neuronal protein.

Specificity

Human, Rat, Pig, Chicken, Zebrafish

Antibody Isotype

IgG2b, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Elav Like Rna Binding Protein 3

Introduction

ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. ELAVL3 is one of several Hu antigens recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis.

Entrez Gene ID

Human	1995
Pig	100515074
Rat	282824
Zebrafish	30732

UniProt ID

Human	Q14576
Pig	F1SA16
Rat	Q76IJ9
Zebrafish	P79736

Alternative Names

HUC; HUCL; PLE21

Research Area

RNA-binding protein that binds to AU-rich element (ARE) sequences of target mRNAs, including VEGF mRNA (PubMed:10710437).

May also bind poly-A tracts via RRM 3 (By similarity).

May be involved in neuronal differentiation and maintenance (By similarity).

Plays a role in the stabilization of GAP43 mRNA and in spatial learning (By similarity).

Biological Process

Cell differentiation Source: UniProtKB-KW
Nervous system development Source: UniProtKB-KW

Cellular Location

Ribonucleoprotein complex

References

Lu, Y. L., Liu, Y., McCoy, M. J., & Yoo, A. S. (2021). MiR-124 synergism with ELAVL3 enhances target gene expression to promote neuronal maturity. Proceedings of the National Academy of Sciences, 118(22), e2015454118.

Diaz-Garcia, S., Ko, V. I., Vazquez-Sanchez, S., Chia, R., Arogundade, O. A., Rodriguez, M. J., ... & Ravits, J. (2021). Nuclear depletion of RNA-binding protein ELAVL3 (HuC) in sporadic and familial amyotrophic lateral sclerosis. Acta neuropathologica, 142(6), 985-1001.

Grassi, E., Santoro, R., Umbach, A., Grosso, A., Oliviero, S., Neri, F., ... & Merlo, G. R. (2019). Choice of alternative polyadenylation sites, mediated by the RNA-binding protein Elavl3, plays a role in differentiation of inhibitory neuronal progenitors. Frontiers in cellular neuroscience, 12, 518.

Ogawa, Y., Yamaguchi, J., Yano, M., Uchiyama, Y., & Okano, H. J. (2018). Elavl3 regulates neuronal polarity through the alternative splicing of an embryo-specific exon in AnkyrinG. Neuroscience Research, 135, 13-20.

Ogawa, Y., Kakumoto, K., Yoshida, T., Kuwako, K. I., Miyazaki, T., Yamaguchi, J., ... & Okano, H. J. (2018). Elavl3 is essential for the maintenance of Purkinje neuron axons. Scientific reports, 8(1), 1-13.

Q & As

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Review & reward

Have you used Mouse Anti-ELAVL3 Monoclonal Antibody (16A11)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-ELAVL3 Recombinant Antibody (CBFYE-0764)

Mouse Anti-ELAVL3 Recombinant Antibody (CBFYH-0148)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote

Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email: