Mouse Anti-ELAVL3 Recombinant Antibody (CBFYE-0764) (V2LY-0825-LY46)

Name: Mouse Anti-ELAVL3 Recombinant Antibody (CBFYE-0764)
SKU: V2LY-0825-LY46
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYE-0764

Application

WB, IF, ELISA, IHC-P, FC

Immunogen

Human HuC/HuD neuronal protein.

Host Species

Mouse

Specificity

Chicken, Human, Zebrafish, Mouse, Rat

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
IF(ICC)	5-20 µg/ml
IHC-P	5-20 µg/ml
WB	1-5 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

HEPES

Preservative

None

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Elav Like Rna Binding Protein 3

Entrez Gene ID

1995

UniProt ID

Q14576

Research Area

RNA-binding protein that binds to AU-rich element (ARE) sequences of target mRNAs, including VEGF mRNA (PubMed:10710437).

May also bind poly-A tracts via RRM 3 (By similarity).

May be involved in neuronal differentiation and maintenance (By similarity).

Plays a role in the stabilization of GAP43 mRNA and in spatial learning (By similarity).

Biological Process

Cell differentiation Source: UniProtKB-KW
Nervous system development Source: UniProtKB-KW

Cellular Location

Ribonucleoprotein complex

Lu, Y. L., Liu, Y., McCoy, M. J., & Yoo, A. S. (2021). MiR-124 synergism with ELAVL3 enhances target gene expression to promote neuronal maturity. Proceedings of the National Academy of Sciences, 118(22), e2015454118.

Diaz-Garcia, S., Ko, V. I., Vazquez-Sanchez, S., Chia, R., Arogundade, O. A., Rodriguez, M. J., ... & Ravits, J. (2021). Nuclear depletion of RNA-binding protein ELAVL3 (HuC) in sporadic and familial amyotrophic lateral sclerosis. Acta neuropathologica, 142(6), 985-1001.

Grassi, E., Santoro, R., Umbach, A., Grosso, A., Oliviero, S., Neri, F., ... & Merlo, G. R. (2019). Choice of alternative polyadenylation sites, mediated by the RNA-binding protein Elavl3, plays a role in differentiation of inhibitory neuronal progenitors. Frontiers in cellular neuroscience, 12, 518.

Ogawa, Y., Yamaguchi, J., Yano, M., Uchiyama, Y., & Okano, H. J. (2018). Elavl3 regulates neuronal polarity through the alternative splicing of an embryo-specific exon in AnkyrinG. Neuroscience Research, 135, 13-20.

Ogawa, Y., Kakumoto, K., Yoshida, T., Kuwako, K. I., Miyazaki, T., Yamaguchi, J., ... & Okano, H. J. (2018). Elavl3 is essential for the maintenance of Purkinje neuron axons. Scientific reports, 8(1), 1-13.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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