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Rabbit Anti-ERAS Recombinant Antibody (D5G5J) (CBMAB-CP0628-LY)

The product is antibody recognizes ERAS. The antibody D5G5J immunoassay techniques such as: WB.
See all ERAS antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse
Clone
D5G5J
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala30 of human E-Ras protein.
Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
ES Cell Expressed Ras
Introduction
This gene encodes a constitutively active member of the small GTPase Ras protein family. The encoded protein activates the phosphatidylinositol 3-kinase signal transduction pathway in undifferentiated stem cells, but is not expressed in differentiated cells. This gene may be involved in cancer and chemotherapy resistance. [provided by RefSeq, Dec 2012]
Entrez Gene ID
353283
UniProt ID
Q7TN89
Alternative Names
HRAS2; HRasp; Ha-Ras2; ecat5
Research Area
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells (By similarity).
Biological Process
Ras protein signal transduction Source: GO_Central
Cellular Location
Cell membrane

Pudewell, S., Lissy, J., Nakhaeizadeh, H., Taha, M. S., Akbarzadeh, M., Rezaei Adariani, S., ... & Ahmadian, M. R. (2022). Physical interaction between embryonic stem cell-expressed Ras (ERas) and Arginase-1 in quiescent hepatic stellate cells. Cells, 11(3), 508.

Suarez-Cabrera, C., Ojeda-Perez, I., Sanchez-Baltasar, R., Page, A., Bravo, A., Navarro, M., & Ramirez, A. (2021). ERAS, a Member of the Ras Superfamily, Acts as an Oncoprotein in the Mammary Gland. Cancers, 13(21), 5588.

Tian, H., Wang, W., Meng, X., Wang, M., Tan, J., Jia, W., ... & Zhou, Q. (2020). ERas enhances resistance to cisplatin-induced apoptosis by suppressing autophagy in gastric cancer cell. Frontiers in cell and developmental biology, 7, 375.

Liu, Y., Qin, P., Wu, R., Du, L., & Li, F. (2020). ERas regulates cell proliferation and epithelial–mesenchymal transition by affecting Erk/Akt signaling pathway in pancreatic cancer. Human cell, 33(4), 1186-1196.

Pan, J., & Zhao, L. X. (2020). Epithelial-mesenchymal transition suppresses ERas to activate autophagy in retinal pigment epithelial cells in proliferative vitreoretinopathy. Eur Rev Med Pharmacol Sci, 24(9), 4627-4634.

Ikink, G. J., Boer, M., Bakker, E. R., Vendel-Zwaagstra, A., Klijn, C., Ten Hoeve, J., ... & Hilkens, J. (2018). Insertional mutagenesis in a HER2-positive breast cancer model reveals ERAS as a driver of cancer and therapy resistance. Oncogene, 37(12), 1594-1609.

Suárez-Cabrera, C., de la Peña, B., González, L. L., Page, A., Martínez-Fernández, M., Casanova, M. L., ... & Navarro, M. (2018). The Ras-related gene ERAS is involved in human and murine breast cancer. Scientific reports, 8(1), 1-17.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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