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Mouse Anti-ERAS Recombinant Antibody (CBFYE-1088) (CBMAB-E1624-FY)

This product is mouse antibody that recognizes ERAS. The antibody CBFYE-1088 can be used for immunoassay techniques such as: WB.
See all ERAS antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-1088
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
ERAS antibody was raised in mouse using a full length recombinant protein of human ERAS produced in HEK293T cells, as the immunogen
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1%BSA, 50% glycerol
Preservative
0.02% Sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ES Cell Expressed Ras
Introduction
This gene encodes a constitutively active member of the small GTPase Ras protein family. The encoded protein activates the phosphatidylinositol 3-kinase signal transduction pathway in undifferentiated stem cells, but is not expressed in differentiated cells. This gene may be involved in cancer and chemotherapy resistance.
Entrez Gene ID
3266
UniProt ID
Q7Z444
Alternative Names
ES Cell Expressed Ras; V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog Pseudogene; Embryonic Stem Cell-Expressed Ras; HRAS2; HRASP; E-Ras; V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog 2; Small GTPase Protein E-Ras; GTPase ERas
Research Area
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells (By similarity).
Biological Process
Ras protein signal transduction Source: GO_Central
Cellular Location
Cell membrane

Pudewell, S., Lissy, J., Nakhaeizadeh, H., Taha, M. S., Akbarzadeh, M., Rezaei Adariani, S., ... & Ahmadian, M. R. (2022). Physical interaction between embryonic stem cell-expressed Ras (ERas) and Arginase-1 in quiescent hepatic stellate cells. Cells, 11(3), 508.

Suarez-Cabrera, C., Ojeda-Perez, I., Sanchez-Baltasar, R., Page, A., Bravo, A., Navarro, M., & Ramirez, A. (2021). ERAS, a Member of the Ras Superfamily, Acts as an Oncoprotein in the Mammary Gland. Cancers, 13(21), 5588.

Tian, H., Wang, W., Meng, X., Wang, M., Tan, J., Jia, W., ... & Zhou, Q. (2020). ERas enhances resistance to cisplatin-induced apoptosis by suppressing autophagy in gastric cancer cell. Frontiers in cell and developmental biology, 7, 375.

Liu, Y., Qin, P., Wu, R., Du, L., & Li, F. (2020). ERas regulates cell proliferation and epithelial–mesenchymal transition by affecting Erk/Akt signaling pathway in pancreatic cancer. Human cell, 33(4), 1186-1196.

Pan, J., & Zhao, L. X. (2020). Epithelial-mesenchymal transition suppresses ERas to activate autophagy in retinal pigment epithelial cells in proliferative vitreoretinopathy. Eur Rev Med Pharmacol Sci, 24(9), 4627-4634.

Ikink, G. J., Boer, M., Bakker, E. R., Vendel-Zwaagstra, A., Klijn, C., Ten Hoeve, J., ... & Hilkens, J. (2018). Insertional mutagenesis in a HER2-positive breast cancer model reveals ERAS as a driver of cancer and therapy resistance. Oncogene, 37(12), 1594-1609.

Suárez-Cabrera, C., de la Peña, B., González, L. L., Page, A., Martínez-Fernández, M., Casanova, M. L., ... & Navarro, M. (2018). The Ras-related gene ERAS is involved in human and murine breast cancer. Scientific reports, 8(1), 1-17.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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