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Rabbit Anti-ERCC6L Recombinant Antibody (D4G8) (CBMAB-P0316-YC)

Provided herein is a Rabbit monoclonal antibody against Human Excision repair cross-complementation group 6 like. The antibody can be used for immunoassay techniques, such as WB.
See all ERCC6L antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Monkey, Hamster
Clone
D4G8
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human, Monkey, Hamster
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ERCC Excision Repair 6 Like, Spindle Assembly Checkpoint Helicase
Introduction
ERCC6L (ERCC Excision Repair 6 Like, Spindle Assembly Checkpoint Helicase) is a protein coding gene. Among its related pathways are Cell Cycle, Mitotic and Signaling by Rho GTPases. Gene Ontology annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of the gene is PGBD3.
Entrez Gene ID
Human54821
Hamster100757441
Monkey699138
UniProt ID
HumanQ2NKX8
HamsterA0A1U7R5Q4
MonkeyA0A2K5VU19
Alternative Names
PICH; RAD26L
Research Area
DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328).

Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671).

Can promote Holliday junction branch migration (in vitro) (PubMed:23973328).
Biological Process
Cell cycle Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
Cellular Location
Centromere; Kinetochore; Chromosome. Localizes to kinetochores, inner centromeres and thin threads connecting separating chromosomes even during anaphase. In prometaphase cells, it mostly concentrates in between kinetochores. In metaphase, it localizes to numerous thin threads that stretch between sister kinetochores of the aligned chromosomes and are composed of catenated centromeric DNA. Evolution from inner centromeres to thin threads takes place in response to tension. Resolution of thin threads requires topoisomerase 2-alpha (TOP2A) after anaphase onset.
PTM
Phosphorylation by PLK1 prevents the association with chromosome arms and restricts its localization to the kinetochore-centromere region.

Huang, X., Jiang, L., Lu, S., Yuan, M., Lin, H., Li, B., ... & Zhong, Y. (2022). Overexpression of ERCC6L correlates with poor prognosis and confers malignant phenotypes of lung adenocarcinoma. Oncology Reports, 48(1), 1-18.

Hou, G., Lu, Z., Bi, Y., Deng, J., & Yang, X. (2022). ERCC6L is a biomarker and therapeutic target for non–small cell lung adenocarcinoma. Medical Oncology, 39(5), 1-16.

Zhang, G., Yu, Z., Fu, S., Lv, C., Dong, Q., Fu, C., ... & Zeng, Y. (2022). Correction to: ERCC6L that is up-regulated in high grade of renal cell carcinoma enhances cell viability in vitro and promotes tumor growth in vivo potentially through modulating MAPK signalling pathway. Cancer Gene Therapy, 1-1.

Zhang, G., Ma, J., Xiong, J., Huang, X., Han, X., Yu, X., & Jiang, X. (2021). Upregulation of Excision Repair Cross-Complementation Group 6-Like (ERCC6L) Promotes Tumor Growth in Hepatocellular Carcinoma. Digestive Diseases and Sciences, 66(4), 1097-1109.

Chen, D., Liu, Q., & Cao, G. (2021). ERCC6L promotes cell growth and metastasis in gastric cancer through activating NF-κB signaling. Aging (Albany NY), 13(16), 20218.

Yu, B., Liang, H., Ye, Q., & Wang, Y. (2020). Upregulation of ERCC6L is associated with tumor progression and unfavorable prognosis in hepatocellular carcinoma. Journal of Gastrointestinal Oncology, 11(5), 1009.

Chen, H., Wang, H., Yu, X., Zhou, S., Zhang, Y., Wang, Z., ... & Wang, Z. (2020). ERCC6L promotes the progression of hepatocellular carcinoma through activating PI3K/AKT and NF-κB signaling pathway. BMC cancer, 20(1), 1-10.

Xie, Y., Yu, J., Wang, F., Li, M., Qiu, X., Liu, Y., & Qi, J. (2019). ERCC6L promotes cell growth and invasion in human colorectal cancer. Oncology letters, 18(1), 237-246.

Zhang, G., Yu, Z., Fu, S., Lv, C., Dong, Q., Fu, C., ... & Zeng, Y. (2019). ERCC6L that is up-regulated in high grade of renal cell carcinoma enhances cell viability in vitro and promotes tumor growth in vivo potentially through modulating MAPK signalling pathway. Cancer Gene Therapy, 26(9), 323-333.

Liu, J., Sun, J., Zhang, Q., & Zeng, Z. (2018). shRNA knockdown of DNA helicase ERCC6L expression inhibits human breast cancer growth. Molecular Medicine Reports, 18(3), 3490-3496.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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