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ERCC6L Matched Antibody Pair (388) (APMAB-388LY)


See all ERCC6L antibodies
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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-ERCC6L polyclonal antibody, 100 ug
Detection Antibody
Anti-ERCC6L Mouse polyclonal antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes a member of the SWItch/Sucrose Non-Fermentable (SWI/SNF2) family of proteins, and contains a SNF2-like ATPase domain and a PICH family domain. One distinguishing feature of this SWI/SNF protein family member is that during interphase, the protein is excluded from the nucleus, and only associates with chromatin after the nuclear envelope has broken down. This protein is a DNA translocase that is thought to bind double-stranded DNA that is exposed to stretching forces, such as those exerted by the mitotic spindle. This protein associates with ribosomal DNA and ultra-fine DNA bridges (UFBs), fine structures that connect sister chromatids during anaphase at some sites such as fragile sites, telomeres and centromeres. This gene is required for the faithful segregation of sister chromatids during mitosis, and the ATPase activity of this protein required for the resolution of UFBs before cytokinesis. [provided by RefSeq, May 2017]
Alternative Names
ERCC Excision Repair 6 Like, Spindle Assembly Checkpoint Helicase; Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6-Like; Excision Repair Cross-Complementation Group 6 Like; PLK1-Interacting Checkpoint Helicase; ATP-Dependent Helicase ERCC6-Like; Tumor Antigen BJ-HCC-15; PICH; Excision Repair Cross-Complementing Rodent Repair Deficiency Complementation Group 6 - Like;
Entrez Gene ID
54821
UniProt ID
Q2NKX8
More Infomation

Huang, X., Jiang, L., Lu, S., Yuan, M., Lin, H., Li, B., ... & Zhong, Y. (2022). Overexpression of ERCC6L correlates with poor prognosis and confers malignant phenotypes of lung adenocarcinoma. Oncology Reports, 48(1), 1-18.

Hou, G., Lu, Z., Bi, Y., Deng, J., & Yang, X. (2022). ERCC6L is a biomarker and therapeutic target for non–small cell lung adenocarcinoma. Medical Oncology, 39(5), 1-16.

Zhang, G., Yu, Z., Fu, S., Lv, C., Dong, Q., Fu, C., ... & Zeng, Y. (2022). Correction to: ERCC6L that is up-regulated in high grade of renal cell carcinoma enhances cell viability in vitro and promotes tumor growth in vivo potentially through modulating MAPK signalling pathway. Cancer Gene Therapy, 1-1.

Zhang, G., Ma, J., Xiong, J., Huang, X., Han, X., Yu, X., & Jiang, X. (2021). Upregulation of Excision Repair Cross-Complementation Group 6-Like (ERCC6L) Promotes Tumor Growth in Hepatocellular Carcinoma. Digestive Diseases and Sciences, 66(4), 1097-1109.

Chen, D., Liu, Q., & Cao, G. (2021). ERCC6L promotes cell growth and metastasis in gastric cancer through activating NF-κB signaling. Aging (Albany NY), 13(16), 20218.

Yu, B., Liang, H., Ye, Q., & Wang, Y. (2020). Upregulation of ERCC6L is associated with tumor progression and unfavorable prognosis in hepatocellular carcinoma. Journal of Gastrointestinal Oncology, 11(5), 1009.

Chen, H., Wang, H., Yu, X., Zhou, S., Zhang, Y., Wang, Z., ... & Wang, Z. (2020). ERCC6L promotes the progression of hepatocellular carcinoma through activating PI3K/AKT and NF-κB signaling pathway. BMC cancer, 20(1), 1-10.

Xie, Y., Yu, J., Wang, F., Li, M., Qiu, X., Liu, Y., & Qi, J. (2019). ERCC6L promotes cell growth and invasion in human colorectal cancer. Oncology letters, 18(1), 237-246.

Zhang, G., Yu, Z., Fu, S., Lv, C., Dong, Q., Fu, C., ... & Zeng, Y. (2019). ERCC6L that is up-regulated in high grade of renal cell carcinoma enhances cell viability in vitro and promotes tumor growth in vivo potentially through modulating MAPK signalling pathway. Cancer Gene Therapy, 26(9), 323-333.

Liu, J., Sun, J., Zhang, Q., & Zeng, Z. (2018). shRNA knockdown of DNA helicase ERCC6L expression inhibits human breast cancer growth. Molecular Medicine Reports, 18(3), 3490-3496.

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For research use only. Not intended for any clinical use.

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