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Rabbit Anti-ETS2 Recombinant Antibody (D6L4J) (CBMAB-CP0653-LY)

The product is antibody recognizes ETS2. The antibody D6L4J immunoassay techniques such as: WB,IF (ICC).
See all ETS2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
D6L4J
Antibody Isotype
IgG
Application
WB, IF (ICC)

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu201 of human ETS-2 protein.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
ETS Proto-Oncogene 2, Transcription Factor
Introduction
This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Entrez Gene ID
2114
UniProt ID
P15036
Alternative Names
ETS Proto-Oncogene 2; Transcription Factor; V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog 2; V-Ets Erythroblastosis Virus E26 Oncogene Homolog 2 (Avian); V-Ets Avian Erythroblastosis Virus E2 Oncogene Homolog 2; V-Ets Erythroblastosis Virus E26 Oncogene Homolog 2; Protein C-Ets-2; Oncogene ETS-2; ETS2IT1;
Research Area
Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription.
Biological Process
Cell differentiation Source: GO_Central
Ectodermal cell fate commitment Source: Ensembl
Mesoderm development Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Positive regulation of transcription, DNA-templated Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Primitive streak formation Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Skeletal system development Source: ProtInc
Cellular Location
Nucleus
PTM
Phosphorylation by CDK10 at Ser-220 and Ser-225 creates a phosphodegron that targets ETS2 for proteasomal degradation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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