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ETS2

This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Full Name

ETS Proto-Oncogene 2, Transcription Factor

Research Area

Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription.

Biological Process

Cell differentiation Source: GO_Central
Ectodermal cell fate commitment Source: Ensembl
Mesoderm development Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Positive regulation of transcription, DNA-templated Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Primitive streak formation Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Skeletal system development Source: ProtInc

Cellular Location

Nucleus

PTM

Phosphorylation by CDK10 at Ser-220 and Ser-225 creates a phosphodegron that targets ETS2 for proteasomal degradation.

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Anti-ETS2 antibodies

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Mouse Anti-ETS2 Recombinant Antibody (CBFYE-1347) (CBMAB-E1959-FY)

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Target: ETS2

Host: Mouse

Antibody Isotype: IgM, κ

Specificity: Human, Mouse, Rat

Clone: CBFYE-1347

Application*: WB, IP, IF, E

Rabbit Anti-ETS2 Recombinant Antibody (CP0653) (V2LY-0825-LY867)

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Target: ETS2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: CP0653

Application*: WB

Mouse Anti-ETS2 Recombinant Antibody (CBFYE-1348) (V2LY-0825-LY866)

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Target: ETS2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human, Mouse, Rat, Dog, Cattle

Clone: CBFYE-1348

Application*: WB, IP, IF, E

Mouse Anti-ETS2 Recombinant Antibody (CBFYE-1346) (V2LY-0825-LY864)

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Target: ETS2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse, Rat

Clone: CBFYE-1346

Application*: WB, IH

Mouse Anti-ETS2 Recombinant Antibody (E1960) (V2LY-0825-LY863)

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Target: ETS2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat, Dog, Cattle

Clone: E1960

Application*: WB, IP, IF, E

Mouse Anti-ETS2 Monoclonal Antibody (1D9) (CBMAB-0361-YC)

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Target: ETS2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 1D9

Application*: E, IP

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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