Mouse Anti-ETS2 Recombinant Antibody (CBFYE-1347) (CBMAB-E1959-FY)

Name: Mouse Anti-ETS2 Recombinant Antibody (CBFYE-1347)
SKU: CBMAB-E1959-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYE-1347

Application

WB, IP, IF, ELISA

Immunogen

Amino acids 161-300 of human Ets-2.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgM, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
ELISA	1:100-1:1,000
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, gelatin

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Epitope

AA 90-349

More Infomation

Target

Full Name

ETS Proto-Oncogene 2, Transcription Factor

Introduction

This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants.

Entrez Gene ID

Human	2114
Mouse	23872

UniProt ID

Human	P15036
Mouse	P15037

Alternative Names

ETS Proto-Oncogene 2, Transcription Factor; V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog 2; V-Ets Erythroblastosis Virus E26 Oncogene Homolog 2 (Avian); V-Ets Avian Erythroblastosis Virus E2 Oncogene Homolog 2; V-Ets Erythroblastosis Virus E26 Oncogene Homolog 2; Protein C-Ets-2; Oncogene ETS-2; ETS2IT1

Research Area

Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription.

Biological Process

Cell differentiation Source: GO_Central
Ectodermal cell fate commitment Source: Ensembl
Mesoderm development Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Positive regulation of transcription, DNA-templated Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Primitive streak formation Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Skeletal system development Source: ProtInc

Cellular Location

Nucleus

PTM

Phosphorylation by CDK10 at Ser-220 and Ser-225 creates a phosphodegron that targets ETS2 for proteasomal degradation.

Wang, H., Huang, R., Guo, W., Qin, X., Yang, Z., Yuan, Z., ... & Wang, H. (2020). RNA-binding protein CELF1 enhances cell migration, invasion, and chemoresistance by targeting ETS2 in colorectal cancer. Clinical Science, 134(14), 1973-1990.

Fry, E. A., & Inoue, K. (2018). Aberrant expression of ETS1 and ETS2 proteins in cancer. Cancer reports and reviews, 2(3).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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