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Mouse Anti-FABP3 Recombinant Antibody (5B5) (CBMAB-C7330-LY)

This product is antibody recognizes FABP3. The antibody 5B5 immunoassay techniques such as: ELISA.
See all FABP3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
5B5
Antibody Isotype
IgG1
Application
ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
2 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Fatty Acid Binding Protein 3
Introduction
The intracellular fatty acid-binding proteins (FABPs) belongs to a multigene family. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Fatty acid-binding protein 3 gene contains four exons and its function is to arrest growth of mammary epithelial cells. This gene is a candidate tumor suppressor gene for human breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Entrez Gene ID
2170
UniProt ID
P05413
Alternative Names
Fatty Acid Binding Protein 3; Mammary-Derived Growth Inhibitor; Fatty Acid Binding Protein 3, Muscle And Heart; Heart-Type Fatty Acid-Binding Protein; Muscle Fatty Acid-Binding Protein; Fatty Acid Binding Protein 11; FABP11; H-FABP;
Research Area
FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.
Biological Process
Brown fat cell differentiation Source: Ensembl
Cholesterol homeostasis Source: BHF-UCL
Fatty acid metabolic process Source: Ensembl
Intracellular lipid transport Source: BHF-UCL
Long-chain fatty acid transport Source: ARUK-UCL
Negative regulation of cell population proliferation Source: ProtInc
Phospholipid homeostasis Source: BHF-UCL
Positive regulation of long-chain fatty acid import into cell Source: ARUK-UCL
Positive regulation of phospholipid biosynthetic process Source: BHF-UCL
Regulation of fatty acid oxidation Source: BHF-UCL
Regulation of phosphatidylcholine biosynthetic process Source: Ensembl
Response to drug Source: Ensembl
Response to fatty acid Source: Ensembl
Response to insulin Source: Ensembl
Cellular Location
Cytoplasm

Dogra, A., Kour, D., Gour, A., Bhardwaj, M., Bag, S., Dhiman, S. K., ... & Nandi, U. (2022). Ameliorating effect of rutin against diclofenac-induced cardiac injury in rats with underlying function of FABP3, MYL3, and ANP. Drug and Chemical Toxicology, 1-12.

Liu, Z. Z., Hong, C. G., Hu, W. B., Chen, M. L., Duan, R., Li, H. M., ... & Xie, H. (2021). Autophagy receptor OPTN (optineurin) regulates mesenchymal stem cell fate and bone-fat balance during aging by clearing FABP3. Autophagy, 17(10), 2766-2782.

Matsuo, K., Kawahata, I., Melki, R., Bousset, L., Owada, Y., & Fukunaga, K. (2021). Suppression of α-synuclein propagation after intrastriatal injection in FABP3 null mice. Brain research, 1760, 147383.

Lee, S. M., Lee, S. H., Jung, Y., Lee, Y., Yoon, J. H., Choi, J. Y., ... & Kwon, K. S. (2020). FABP3-mediated membrane lipid saturation alters fluidity and induces ER stress in skeletal muscle with aging. Nature communications, 11(1), 1-15.

Ayo, A., Figueras, E., Schachtsiek, T., Budak, M., Sewald, N., & Laakkonen, P. (2020). Tumor-Targeting Peptides: The Functional Screen of Glioblastoma Homing Peptides to the Target Protein FABP3 (MDGI). Cancers, 12(7), 1836.

Bi, Y., Yuan, X., Zhu, P., Chen, Y., Chen, G., & Chang, G. (2020). A novel long noncoding RNA, ENSGALG00000021686, regulates the intracellular transport of fatty acids by targeting the FABP3 gene in chicken. Biochemical and Biophysical Research Communications, 528(4), 706-712.

Cheng, A., Shinoda, Y., Yamamoto, T., Miyachi, H., & Fukunaga, K. (2019). Development of FABP3 ligands that inhibit arachidonic acid-induced α-synuclein oligomerization. Brain research, 1707, 190-197.

Yamamoto, Y., Kida, H., Kagawa, Y., Yasumoto, Y., Miyazaki, H., Islam, A., ... & Owada, Y. (2018). FABP3 in the anterior cingulate cortex modulates the methylation status of the glutamic acid decarboxylase67 promoter region. Journal of Neuroscience, 38(49), 10411-10423.

Sepe, F. N., Chiasserini, D., & Parnetti, L. (2018). Role of FABP3 as biomarker in Alzheimer's disease and synucleinopathies. Future Neurology, 13(4), 199-207.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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