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Mouse Anti-FABP4 Recombinant Antibody (CAP736) (CBMAB-AP2182LY)


See all FABP4 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CAP736
Antibody Isotype
IgG
Application
IHC, WB

Basic Information

Immunogen
A synthetic peptide of human FABP4
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Fatty Acid Binding Protein 4
Introduction
FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human2167
Mouse11770
UniProt ID
HumanP15090
MouseP04117
Alternative Names
Fatty Acid Binding Protein 4; Adipocyte-Type Fatty Acid-Binding Protein; Adipocyte Fatty Acid Binding Protein; Adipocyte Lipid-Binding Protein; A-FABP; AFABP; ALBP;
Research Area
Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.
Biological Process
Brown fat cell differentiation Source: Ensembl
Cellular response to lithium ion Source: Ensembl
Cellular response to tumor necrosis factor Source: Ensembl
Cholesterol homeostasis Source: Ensembl
Long-chain fatty acid transport Source: UniProtKB
Negative regulation of protein kinase activity Source: Ensembl
Negative regulation of transcription, DNA-templated Source: Ensembl
Positive regulation of cold-induced thermogenesis Source: YuBioLab
Positive regulation of inflammatory response Source: Ensembl
Response to bacterium Source: Ensembl
White fat cell differentiation Source: Ensembl
Cellular Location
Nucleus; Cytoplasm. Depending on the nature of the ligand, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus. Subject to constitutive nuclear export.

Guo, D., Lin, C., Lu, Y., Guan, H., Qi, W., Zhang, H., ... & Cai, D. (2022). FABP4 secreted by M1-polarized macrophages promotes synovitis and angiogenesis to exacerbate rheumatoid arthritis. Bone Research, 10(1), 1-15.

Floresta, G., Patamia, V., Zagni, C., & Rescifina, A. (2022). Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. An update from 2017 to early 2022. European Journal of Medicinal Chemistry, 114604.

Prentice, K. J., Saksi, J., Robertson, L. T., Lee, G. Y., Inouye, K. E., Eguchi, K., ... & Hotamisligil, G. S. (2021). A hormone complex of FABP4 and nucleoside kinases regulates islet function. Nature, 600(7890), 720-726.

Tian, W., Zhang, W., Zhang, Y., Zhu, T., Hua, Y., Li, H., ... & Xia, M. (2020). FABP4 promotes invasion and metastasis of colon cancer by regulating fatty acid transport. Cancer cell international, 20(1), 1-13.

Zeng, J., Sauter, E. R., & Li, B. (2020). FABP4: a new player in obesity-associated breast cancer. Trends in molecular medicine, 26(5), 437-440.

Mukherjee, A., Chiang, C. Y., Daifotis, H. A., Nieman, K. M., Fahrmann, J. F., Lastra, R. R., ... & Lengyel, E. (2020). Adipocyte-induced FABP4 expression in ovarian cancer cells promotes metastasis and mediates carboplatin resistance. Cancer research, 80(8), 1748-1761.

Prentice, K. J., Saksi, J., & Hotamisligil, G. S. (2019). Adipokine FABP4 integrates energy stores and counterregulatory metabolic responses. Journal of Lipid Research, 60(4), 734-740.

Zhang, Y., Zhao, X., Deng, L., Li, X., Wang, G., Li, Y., & Chen, M. (2019). High expression of FABP4 and FABP6 in patients with colorectal cancer. World Journal of Surgical Oncology, 17(1), 1-13.

Tirosh, A., Calay, E. S., Tuncman, G., Claiborn, K. C., Inouye, K. E., Eguchi, K., ... & Hotamisligil, G. S. (2019). The short-chain fatty acid propionate increases glucagon and FABP4 production, impairing insulin action in mice and humans. Science translational medicine, 11(489), eaav0120.

Gharpure, K. M., Pradeep, S., Sans, M., Rupaimoole, R., Ivan, C., Wu, S. Y., ... & Sood, A. K. (2018). FABP4 as a key determinant of metastatic potential of ovarian cancer. Nature communications, 9(1), 1-14.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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