Mouse Anti-FABP4 Recombinant Antibody (CBXF-2385) (CBMAB-F2710-CQ)

Name: Mouse Anti-FABP4 Recombinant Antibody (CBXF-2385)
SKU: CBMAB-F2710-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-2385

Application

ELISA, WB, IP

Immunogen

Full length recombinant FABP4.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Fatty Acid Binding Protein 4

Introduction

FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism.

Entrez Gene ID

2167

UniProt ID

P15090

Alternative Names

Fatty Acid Binding Protein 4; Adipocyte-Type Fatty Acid-Binding Protein; Adipocyte Fatty Acid Binding Protein; Adipocyte Lipid-Binding Protein; A-FABP; AFABP; ALBP;

Research Area

Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.

Biological Process

Brown fat cell differentiation Source: Ensembl
Cellular response to lithium ion Source: Ensembl
Cellular response to tumor necrosis factor Source: Ensembl
Cholesterol homeostasis Source: Ensembl
Long-chain fatty acid transport Source: UniProtKB
Negative regulation of protein kinase activity Source: Ensembl
Negative regulation of transcription, DNA-templated Source: Ensembl
Positive regulation of cold-induced thermogenesis Source: YuBioLab
Positive regulation of inflammatory response Source: Ensembl
Response to bacterium Source: Ensembl
White fat cell differentiation Source: Ensembl

Cellular Location

Nucleus; Cytoplasm. Depending on the nature of the ligand, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus. Subject to constitutive nuclear export.

Guo, D., Lin, C., Lu, Y., Guan, H., Qi, W., Zhang, H., ... & Cai, D. (2022). FABP4 secreted by M1-polarized macrophages promotes synovitis and angiogenesis to exacerbate rheumatoid arthritis. Bone Research, 10(1), 1-15.

Floresta, G., Patamia, V., Zagni, C., & Rescifina, A. (2022). Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. An update from 2017 to early 2022. European Journal of Medicinal Chemistry, 114604.

Prentice, K. J., Saksi, J., Robertson, L. T., Lee, G. Y., Inouye, K. E., Eguchi, K., ... & Hotamisligil, G. S. (2021). A hormone complex of FABP4 and nucleoside kinases regulates islet function. Nature, 600(7890), 720-726.

Tian, W., Zhang, W., Zhang, Y., Zhu, T., Hua, Y., Li, H., ... & Xia, M. (2020). FABP4 promotes invasion and metastasis of colon cancer by regulating fatty acid transport. Cancer cell international, 20(1), 1-13.

Zeng, J., Sauter, E. R., & Li, B. (2020). FABP4: a new player in obesity-associated breast cancer. Trends in molecular medicine, 26(5), 437-440.

Mukherjee, A., Chiang, C. Y., Daifotis, H. A., Nieman, K. M., Fahrmann, J. F., Lastra, R. R., ... & Lengyel, E. (2020). Adipocyte-induced FABP4 expression in ovarian cancer cells promotes metastasis and mediates carboplatin resistance. Cancer research, 80(8), 1748-1761.

Prentice, K. J., Saksi, J., & Hotamisligil, G. S. (2019). Adipokine FABP4 integrates energy stores and counterregulatory metabolic responses. Journal of Lipid Research, 60(4), 734-740.

Zhang, Y., Zhao, X., Deng, L., Li, X., Wang, G., Li, Y., & Chen, M. (2019). High expression of FABP4 and FABP6 in patients with colorectal cancer. World Journal of Surgical Oncology, 17(1), 1-13.

Tirosh, A., Calay, E. S., Tuncman, G., Claiborn, K. C., Inouye, K. E., Eguchi, K., ... & Hotamisligil, G. S. (2019). The short-chain fatty acid propionate increases glucagon and FABP4 production, impairing insulin action in mice and humans. Science translational medicine, 11(489), eaav0120.

Gharpure, K. M., Pradeep, S., Sans, M., Rupaimoole, R., Ivan, C., Wu, S. Y., ... & Sood, A. K. (2018). FABP4 as a key determinant of metastatic potential of ovarian cancer. Nature communications, 9(1), 1-14.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

FABP4 Matched Antibody Pair (404) (CAT#: APMAB-404LY)

FABP4 Matched Antibody Pair (405) (CAT#: APMAB-405LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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