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Mouse Anti-FAM35A Recombinant Antibody (2F9) (CBMAB-A2819-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2F9
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
FAM35A (AAH51863.1, 1 a.a. ~ 835 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
family with sequence similarity 35, member A
Entrez Gene ID
54537
UniProt ID
Q86V20
Alternative Names
FAM35A1; MGC5560; bA163M19.1
Research Area
Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893, PubMed:29789392).

During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893, PubMed:29789392).

Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893).
Biological Process
DNA repair Source: UniProtKB-KW
Negative regulation of double-strand break repair via homologous recombination Source: UniProtKB
Positive regulation of double-strand break repair via nonhomologous end joining Source: UniProtKB
Positive regulation of isotype switching Source: UniProtKB
Regulation of double-strand break repair via homologous recombination Source: GO_Central
Cellular Location
Nucleus; Chromosome. Localizes to nuclear foci in response to DNA damage.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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