FAM35A

FAM35A (Family With Sequence Similarity 35 Member A) is a Protein Coding gene.

Full Name

family with sequence similarity 35, member A

Research Area

Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893, PubMed:29789392).

During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893, PubMed:29789392).

Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893).

Biological Process

DNA repair Source: UniProtKB-KW
Negative regulation of double-strand break repair via homologous recombination Source: UniProtKB
Positive regulation of double-strand break repair via nonhomologous end joining Source: UniProtKB
Positive regulation of isotype switching Source: UniProtKB
Regulation of double-strand break repair via homologous recombination Source: GO_Central

Cellular Location

Nucleus; Chromosome. Localizes to nuclear foci in response to DNA damage.