Mouse Anti-FAM35A Recombinant Antibody (CBXF-2830) (CBMAB-F3540-CQ)

Name: Mouse Anti-FAM35A Recombinant Antibody (CBXF-2830)
SKU: CBMAB-F3540-CQ
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBXF-2830

Antibody Isotype

IgG

Application

ELISA, WB

Basic Information

Immunogen

FAM35A (AAH51863.1, aa1-835) full-length recombinant protein with GST tag

Specificity

Human

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

family with sequence similarity 35, member A

Introduction

FAM35A (Family With Sequence Similarity 35 Member A) is a Protein Coding gene.

Entrez Gene ID

54537

UniProt ID

Q86V20

Alternative Names

Family With Sequence Similarity 35 Member A; Family With Sequence Similarity 35, Member A; Protein FAM35A; BA163M19.1; FAM35A1;

Research Area

Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893, PubMed:29789392).

During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893, PubMed:29789392).

Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893).

Biological Process

DNA repair Source: UniProtKB-KW
Negative regulation of double-strand break repair via homologous recombination Source: UniProtKB
Positive regulation of double-strand break repair via nonhomologous end joining Source: UniProtKB
Positive regulation of isotype switching Source: UniProtKB
Regulation of double-strand break repair via homologous recombination Source: GO_Central

Cellular Location

Nucleus; Chromosome. Localizes to nuclear foci in response to DNA damage.

More Infomation

References

Fackrell, K., Bobins, L., & Tomida, J. (2020). FAM35A/SHLD2/RINN2: A novel determinant of double strand break repair pathway choice and genome stability in cancer. Environmental and Molecular Mutagenesis, 61(7), 709-715.

Findlay, S., Heath, J., Luo, V. M., Malina, A., Morin, T., Coulombe, Y., ... & Orthwein, A. (2018). SHLD 2/FAM 35A co‐operates with REV 7 to coordinate DNA double‐strand break repair pathway choice. The EMBO journal, 37(18), e100158.

Tomida, J., Takata, K. I., Bhetawal, S., Person, M. D., Chao, H. P., Tang, D. G., & Wood, R. D. (2018). FAM 35A associates with REV 7 and modulates DNA damage responses of normal and BRCA 1‐defective cells. The EMBO journal, 37(12), e99543.

Yan, F., Sun, P., Zhao, H., Zhao, C., Zhang, N., & Dai, Y. (2018). Genetic association and functional analysis of rs7903456 in FAM35A gene and hyperuricemia: a population based study. Scientific reports, 8(1), 1-6.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-FAM35A Recombinant Antibody (2F9)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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