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Mouse Anti-FATE1 Recombinant Antibody (1B11) (CBMAB-A2856-LY)

The product is antibody recognizes FATE1. The antibody 1B11 immunoassay techniques such as: WB, ELISA.
See all FATE1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1B11
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
FATE1 (NP_149076, 2 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
fetal and adult testis expressed 1
Entrez Gene ID
89885
UniProt ID
Q969F0
Alternative Names
FATE
Research Area
Involved in the regulation of endoplasmic reticulum (ER)-mitochondria coupling. Negatively regulates the ER-mitochondria distance and Ca2+ transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis (PubMed:27402544).

May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling (PubMed:26567849).
Biological Process
Apoptotic process Source: UniProtKB-KW
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of mitochondrial calcium ion concentration Source: UniProtKB
Cellular Location
Mitochondrion; Mitochondrion outer membrane; Endoplasmic reticulum membrane. Localized to specific membrane structures termed mitochondria-associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria. Also associated with the outer surface of mitochondria at sites that are not in close contact with the ER.
Topology
Helical: 163-181
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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