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Mouse Anti-FATE1 Recombinant Antibody (CBXF-2872) (CBMAB-F3580-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-2872
Antibody Isotype
IgG1, κ
Application
ELISA, IHC, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa2-101 from human FATE1 (NP_149076) with GST tag
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
fetal and adult testis expressed 1
Introduction
This gene encodes a cancer-testis antigen that is highly expressed in hepatocellular carcinomas and other tumors and weakly expressed in normal tissues except testis. The protein is strongly expressed in spermatogonia, primary spermatocytes, and Sertoli cells in seminiferous tubules. This protein may have a role in the control of early testicular differentiation and cell proliferation.
Entrez Gene ID
89885
UniProt ID
Q969F0
Alternative Names
Fetal And Adult Testis Expressed 1; Cancer/Testis Antigen 43; Tumor Antigen BJ-HCC-2; CT43; FATE; Fetal And Adult Testis-Expressed Transcript Protein; BJ-HCC-2 Antigen;
Research Area
Involved in the regulation of endoplasmic reticulum (ER)-mitochondria coupling. Negatively regulates the ER-mitochondria distance and Ca2+ transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis (PubMed:27402544).

May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling (PubMed:26567849).
Biological Process
Apoptotic process Source: UniProtKB-KW
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of mitochondrial calcium ion concentration Source: UniProtKB
Cellular Location
Mitochondrion; Mitochondrion outer membrane; Endoplasmic reticulum membrane. Localized to specific membrane structures termed mitochondria-associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria. Also associated with the outer surface of mitochondria at sites that are not in close contact with the ER.
Topology
Helical: 163-181
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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