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Mouse Anti-FCGRT Recombinant Antibody (CBT4219) (V2LY-0625-LY1077)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT4219
Antibody Isotype
IgG1
Application
FC

Basic Information

Immunogen
Purified recombinant fragment of human FCGRT (AA: extra 24-297) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Fc receptor, IgG, alpha chain transporter
Entrez Gene ID
2217
UniProt ID
P55899
Research Area
Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk (PubMed:7964511, PubMed:10933786).

IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation (PubMed:10998088).

In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB (PubMed:24469444, PubMed:28330995).

(Microbial infection) Acts as an uncoating receptor for a panel of echoviruses including Echovirus 5, 6, 7, 9, 11, 13, 25 and 29.
Biological Process
IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor Source: UniProtKB
Cellular Location
Endosome membrane; Cell membrane
Topology
Extracellular: 24-297
Helical: 298-321
Cytoplasmic: 322-365
More Infomation

Riveros-Mckay, F., Roberts, D., Di Angelantonio, E., Yu, B., Soranzo, N., Danesh, J., ... & Barroso, I. (2022). An expanded genome-wide association study of fructosamine levels identifies RCN3 as a replicating locus and implicates FCGRT as the effector transcript. Diabetes, 71(2), 359-364.

Agrawal, S., Kumar, S., Chaudhary, R., Chauhan, A., Kumar, A., & Sivamani, B. (2022). Detection of nucleotide variants in FCGRT (Fc fragment of IgG, receptor, transporter, alpha) gene and their influence on colostral IgG concentration in Indian water buffalo (Bubalus bubalis). Molecular Biology Reports, 1-9.

Dalakas, M. C., & Spaeth, P. J. (2021). The importance of FcRn in neuro-immunotherapies: from IgG catabolism, FCGRT gene polymorphisms, IVIg dosing and efficiency to specific FcRn inhibitors. Therapeutic advances in neurological disorders, 14, 1756286421997381.

Su, S., Liu, Q., Zhang, X., Wen, X., Lei, L., Shen, F., ... & Da, Y. (2021). VNTR2/VNTR3 genotype in the FCGRT gene is associated with reduced effectiveness of intravenous immunoglobulin in patients with myasthenia gravis. Therapeutic advances in neurological disorders, 14, 1756286420986747.

Low, B. E., Christianson, G. J., Lowell, E., Qin, W., & Wiles, M. V. (2020, January). Functional humanization of immunoglobulin heavy constant gamma 1 Fc domain human FCGRT transgenic mice. In MAbs (Vol. 12, No. 1, p. 1829334). Taylor & Francis.

Cejas, R. B., Ferguson, D. C., Quinones-Lombrana, A., Bard, J. E., & Blanco, J. G. (2019). Contribution of DNA methylation to the expression of FCGRT in human liver and myocardium. Scientific reports, 9(1), 1-10.

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For research use only. Not intended for any clinical use.

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