Sign in or Register   Sign in or Register
  |  

Mouse Anti-FCGRT Recombinant Antibody (CBXF-2230) (CBMAB-F2018-CQ)

This product is a mouse antibody that recognizes FCGRT. The antibody CBXF-2230 can be used for immunoassay techniques such as: IHC.
See all FCGRT antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-2230
Antibody Isotype
IgG2a
Application
IHC

Basic Information

Immunogen
Recombinant protein corresponding to Human FCGRT
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 40% glycerol, pH 7.2
Preservative
0.02% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Fc receptor, IgG, alpha chain transporter
Introduction
This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
2217
UniProt ID
P55899
Alternative Names
Fc Fragment Of IgG Receptor And Transporter; Heavy Chain Of The Major Histocompatibility Complex Class I-Like Fc Receptor; Transmembrane Alpha Chain Of The Neonatal Receptor; Fc Fragment Of IgG, Receptor, Transporter, Alpha; IgG Fc Fragment Receptor Transporter Alpha Chain; Neonatal Fc Receptor; FCRN;
Research Area
Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk (PubMed:7964511, PubMed:10933786).

IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation (PubMed:10998088).

In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB (PubMed:24469444, PubMed:28330995).

(Microbial infection) Acts as an uncoating receptor for a panel of echoviruses including Echovirus 5, 6, 7, 9, 11, 13, 25 and 29.
Biological Process
IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor Source: UniProtKB
Cellular Location
Endosome membrane; Cell membrane
Topology
Extracellular: 24-297
Helical: 298-321
Cytoplasmic: 322-365

Riveros-Mckay, F., Roberts, D., Di Angelantonio, E., Yu, B., Soranzo, N., Danesh, J., ... & Barroso, I. (2022). An expanded genome-wide association study of fructosamine levels identifies RCN3 as a replicating locus and implicates FCGRT as the effector transcript. Diabetes, 71(2), 359-364.

Agrawal, S., Kumar, S., Chaudhary, R., Chauhan, A., Kumar, A., & Sivamani, B. (2022). Detection of nucleotide variants in FCGRT (Fc fragment of IgG, receptor, transporter, alpha) gene and their influence on colostral IgG concentration in Indian water buffalo (Bubalus bubalis). Molecular Biology Reports, 1-9.

Dalakas, M. C., & Spaeth, P. J. (2021). The importance of FcRn in neuro-immunotherapies: from IgG catabolism, FCGRT gene polymorphisms, IVIg dosing and efficiency to specific FcRn inhibitors. Therapeutic advances in neurological disorders, 14, 1756286421997381.

Su, S., Liu, Q., Zhang, X., Wen, X., Lei, L., Shen, F., ... & Da, Y. (2021). VNTR2/VNTR3 genotype in the FCGRT gene is associated with reduced effectiveness of intravenous immunoglobulin in patients with myasthenia gravis. Therapeutic advances in neurological disorders, 14, 1756286420986747.

Low, B. E., Christianson, G. J., Lowell, E., Qin, W., & Wiles, M. V. (2020, January). Functional humanization of immunoglobulin heavy constant gamma 1 Fc domain human FCGRT transgenic mice. In MAbs (Vol. 12, No. 1, p. 1829334). Taylor & Francis.

Cejas, R. B., Ferguson, D. C., Quinones-Lombrana, A., Bard, J. E., & Blanco, J. G. (2019). Contribution of DNA methylation to the expression of FCGRT in human liver and myocardium. Scientific reports, 9(1), 1-10.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-FCGRT Recombinant Antibody (CBXF-2230)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare