Mouse Anti-FCGRT Recombinant Antibody (CBXF-2230) (CBMAB-F2018-CQ)

Name: Mouse Anti-FCGRT Recombinant Antibody (CBXF-2230)
SKU: CBMAB-F2018-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-2230

Application

IHC

Immunogen

Recombinant protein corresponding to Human FCGRT

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 40% glycerol, pH 7.2

Preservative

0.02% sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Fc receptor, IgG, alpha chain transporter

Introduction

This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants.

Entrez Gene ID

2217

UniProt ID

P55899

Alternative Names

Fc Fragment Of IgG Receptor And Transporter; Heavy Chain Of The Major Histocompatibility Complex Class I-Like Fc Receptor; Transmembrane Alpha Chain Of The Neonatal Receptor; Fc Fragment Of IgG, Receptor, Transporter, Alpha; IgG Fc Fragment Receptor Transporter Alpha Chain; Neonatal Fc Receptor; FCRN;

Research Area

Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk (PubMed:7964511, PubMed:10933786).

IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation (PubMed:10998088).

In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB (PubMed:24469444, PubMed:28330995).

(Microbial infection) Acts as an uncoating receptor for a panel of echoviruses including Echovirus 5, 6, 7, 9, 11, 13, 25 and 29.

Biological Process

IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor Source: UniProtKB

Cellular Location

Endosome membrane; Cell membrane

Topology

Extracellular: 24-297
Helical: 298-321
Cytoplasmic: 322-365

Riveros-Mckay, F., Roberts, D., Di Angelantonio, E., Yu, B., Soranzo, N., Danesh, J., ... & Barroso, I. (2022). An expanded genome-wide association study of fructosamine levels identifies RCN3 as a replicating locus and implicates FCGRT as the effector transcript. Diabetes, 71(2), 359-364.

Agrawal, S., Kumar, S., Chaudhary, R., Chauhan, A., Kumar, A., & Sivamani, B. (2022). Detection of nucleotide variants in FCGRT (Fc fragment of IgG, receptor, transporter, alpha) gene and their influence on colostral IgG concentration in Indian water buffalo (Bubalus bubalis). Molecular Biology Reports, 1-9.

Dalakas, M. C., & Spaeth, P. J. (2021). The importance of FcRn in neuro-immunotherapies: from IgG catabolism, FCGRT gene polymorphisms, IVIg dosing and efficiency to specific FcRn inhibitors. Therapeutic advances in neurological disorders, 14, 1756286421997381.

Su, S., Liu, Q., Zhang, X., Wen, X., Lei, L., Shen, F., ... & Da, Y. (2021). VNTR2/VNTR3 genotype in the FCGRT gene is associated with reduced effectiveness of intravenous immunoglobulin in patients with myasthenia gravis. Therapeutic advances in neurological disorders, 14, 1756286420986747.

Low, B. E., Christianson, G. J., Lowell, E., Qin, W., & Wiles, M. V. (2020, January). Functional humanization of immunoglobulin heavy constant gamma 1 Fc domain human FCGRT transgenic mice. In MAbs (Vol. 12, No. 1, p. 1829334). Taylor & Francis.

Cejas, R. B., Ferguson, D. C., Quinones-Lombrana, A., Bard, J. E., & Blanco, J. G. (2019). Contribution of DNA methylation to the expression of FCGRT in human liver and myocardium. Scientific reports, 9(1), 1-10.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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