FCGRT

This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants.
Full Name
Fc receptor, IgG, alpha chain transporter
Research Area
Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk (PubMed:7964511, PubMed:10933786).

IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation (PubMed:10998088).

In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB (PubMed:24469444, PubMed:28330995).

(Microbial infection) Acts as an uncoating receptor for a panel of echoviruses including Echovirus 5, 6, 7, 9, 11, 13, 25 and 29.
Biological Process
IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor Source: UniProtKB
Cellular Location
Endosome membrane; Cell membrane
Topology
Extracellular: 24-297
Helical: 298-321
Cytoplasmic: 322-365
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Anti-FCGRT antibodies

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Mouse Anti-FCGRT Recombinant Antibody (CBT2652) (V2LY-0625-LY1090)

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Target: FCGRT
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT2652
Application*: F
Datasheet SDS

Mouse Anti-FCGRT Recombinant Antibody (CBT4219) (V2LY-0625-LY1077)

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Target: FCGRT
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4219
Application*: F
Datasheet SDS

Mouse Anti-FCGRT Recombinant Antibody (CBXF-2231) (CBMAB-F2019-CQ)

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Target: FCGRT
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-2231
Application*: IH, WB
Datasheet SDS

Mouse Anti-FCGRT Recombinant Antibody (CBXF-2230) (CBMAB-F2018-CQ)

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Target: FCGRT
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-2230
Application*: IH
Datasheet SDS

Mouse Anti-FCGRT Recombinant Antibody (CBXF-3537) (CBMAB-F1066-CQ)

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Target: FCGRT
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBXF-3537
Application*: IF, E, F
Datasheet SDS

Mouse Anti-FCGRT Recombinant Antibody (CBXF-2591) (CBMAB-F0179-CQ)

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Target: FCGRT
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXF-2591
Application*: IS
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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