Sign in or Register   Sign in or Register
  |  

Mouse Anti-FGF5 (AA 23-268) Recombinant Antibody (CBXF-2622) (CBMAB-F3049-CQ)

This product is a mouse antibody that recognizes FGF5 (AA 23-268). The antibody CBXF-2622 can be used for immunoassay techniques such as: IHC.
See all FGF5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-2622
Antibody Isotype
IgG1
Application
IHC

Basic Information

Immunogen
E. coli-derived recombinant human FGF-5 long isoform, Glu23-Gly268 (Lys238Asn, Pro245Ser)
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with trehalose
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 23-268

Target

Full Name
Fibroblast Growth Factor 5
Introduction
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been identified.
Entrez Gene ID
2250
UniProt ID
P12034
Alternative Names
Fibroblast Growth Factor 5; Heparin-Binding Growth Factor 5; Smag-82; HBGF-5; TCMGLY; FGF-5;
Research Area
Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By similarity).
Biological Process
Animal organ morphogenesis Source: GO_Central
Cell-cell signaling Source: ProtInc
Cell differentiation Source: GO_Central
Fibroblast growth factor receptor signaling pathway Source: MGI
Glial cell differentiation Source: Ensembl
Nervous system development Source: ProtInc
Positive regulation of cell division Source: UniProtKB-KW
Positive regulation of cell population proliferation Source: MGI
Positive regulation of gene expression Source: GO_Central
Positive regulation of protein phosphorylation Source: GO_Central
Regulation of cell migration Source: GO_Central
Signal transduction involved in regulation of gene expression Source: Ensembl
Cellular Location
Secreted
Involvement in disease
Trichomegaly (TCMGLY):
A morphologic trait characterized by unusually long eyelashes and mild hypertrichosis of eyebrows. It can be observed in association with corneal irritation, cataracts, and hereditary spherocytosis.

Zhang, G., Zheng, H., & Wang, L. (2022). miR‑491‑3p functions as a tumor suppressor in non‑small cell lung cancer by targeting fibroblast growth factor 5. Oncology Reports, 48(3), 1-12.

Hoang, S. H. (2022). Fibroblast Growth Factor 5 (FGF5) and Its Missense Mutant FGF5-Y174H Underlying Trichomegaly: A Molecular Dynamics Simulation Investigation. bioRxiv.

Shaffer, G. D., Ballif, B. C., Meurs, K., Shaffer, L. G., & Flores-Smith, H. (2021). Identification of a novel missense mutation in the fibroblast growth factor 5 gene associated with longhair in the Maine Coon Cat. Human Genetics, 140(11), 1517-1523.

Xu, Y., Liu, H., Pan, H., Wang, X., Zhang, Y., Yao, B., ... & Li, Z. (2020). CRISPR/Cas9-mediated disruption of fibroblast growth factor 5 in rabbits results in a systemic long hair phenotype by prolonging anagen. Genes, 11(3), 297.

Li, H., & Lipsett, K. A. (2019). The Association of Fibroblast Growth Factor 5 (FGF5), Fibroblast Growth Factor Receptor 1 (FGFR1), and Prolactin (PRL) with Hair Length in Scottish Highland Cattle. The FASEB Journal, 33(S1), 474-9.

McLean*, D., Cunningham, K., & Ricke, W. (2019). Mp68-20 establishing a negative feedback loop between fibroblast growth factor 5 and androgen receptor in prostate cancer. The Journal of Urology, 201(Supplement 4), e983-e983.

Zhou, Y., Yu, Q., Chu, Y., Zhu, X., Deng, J., Liu, Q., & Wang, Q. (2019). Downregulation of fibroblast growth factor 5 inhibits cell growth and invasion of human nonsmall‐cell lung cancer cells. Journal of Cellular Biochemistry, 120(5), 8238-8246.

Huang, Y., Wang, H., & Yang, Y. (2018). Expression of fibroblast growth factor 5 (FGF5) and its influence on survival of breast cancer patients. Medical science monitor: international medical journal of experimental and clinical research, 24, 3524.

Ren, Y., Jiao, X., & Zhang, L. (2018). Expression level of fibroblast growth factor 5 (FGF5) in the peripheral blood of primary hypertension and its clinical significance. Saudi journal of biological sciences, 25(3), 469-473.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-FGF5 (AA 23-268) Recombinant Antibody (CBXF-2622)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare