FGF5

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Full Name
Fibroblast Growth Factor 5
Research Area
Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By similarity).
Biological Process
Animal organ morphogenesis Source: GO_Central
Cell-cell signaling Source: ProtInc
Cell differentiation Source: GO_Central
Fibroblast growth factor receptor signaling pathway Source: MGI
Glial cell differentiation Source: Ensembl
Nervous system development Source: ProtInc
Positive regulation of cell division Source: UniProtKB-KW
Positive regulation of cell population proliferation Source: MGI
Positive regulation of gene expression Source: GO_Central
Positive regulation of protein phosphorylation Source: GO_Central
Regulation of cell migration Source: GO_Central
Signal transduction involved in regulation of gene expression Source: Ensembl
Cellular Location
Secreted
Involvement in disease
Trichomegaly (TCMGLY):
A morphologic trait characterized by unusually long eyelashes and mild hypertrichosis of eyebrows. It can be observed in association with corneal irritation, cataracts, and hereditary spherocytosis.
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Anti-FGF5 antibodies

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Mouse Fgf5 ELISA Kit (V2LY-0626-LY5865)

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Target: Fgf5
Sensitivity: 0.0093 ng/mL
Detection Range: 0.02-4.5 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Datasheet SDS

Human FGF5 ELISA Kit (V2LY-0626-LY4583)

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Target: FGF5
Sensitivity: 0.0053 ng/mL
Detection Range: 0.01-2 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Mouse Anti-FGF5 Recombinant Antibody (CBXF-2161) (V2LY-0925-LY1590)

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Target: FGF5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-2161
Application*: E, WB, IP, PLA
Datasheet SDS

Mouse Anti-FGF5 Recombinant Antibody (CBXF-0584) (V2LY-0925-LY1588)

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Target: FGF5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-0584
Application*: WB
Datasheet SDS

Mouse Anti-FGF5 Recombinant Antibody (CBXF-2534) (V2LY-0925-LY1587)

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Target: FGF5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-2534
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-FGF5 Recombinant Antibody (CBXF-0582) (V2LY-0925-LY1586)

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Target: FGF5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-0582
Application*: E, WB, I
Functional Assay
Datasheet SDS

Mouse Anti-FGF5 Recombinant Antibody (CBFYH-0193) (V2LY-0925-LY1585)

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Target: FGF5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0193
Application*: E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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