Mouse Anti-FGF5 Recombinant Antibody (CBXF-2983) (CBMAB-F3689-CQ)

Name: Mouse Anti-FGF5 Recombinant Antibody (CBXF-2983)
SKU: CBMAB-F3689-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-2983

Application

ELISA

Immunogen

Recombinant human FGF-5

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Fibroblast Growth Factor 5

Introduction

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been identified.

Entrez Gene ID

2250

UniProt ID

P12034

Alternative Names

Fibroblast Growth Factor 5; Heparin-Binding Growth Factor 5; Smag-82; HBGF-5; TCMGLY; FGF-5;

Research Area

Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By similarity).

Biological Process

Animal organ morphogenesis Source: GO_Central
Cell-cell signaling Source: ProtInc
Cell differentiation Source: GO_Central
Fibroblast growth factor receptor signaling pathway Source: MGI
Glial cell differentiation Source: Ensembl
Nervous system development Source: ProtInc
Positive regulation of cell division Source: UniProtKB-KW
Positive regulation of cell population proliferation Source: MGI
Positive regulation of gene expression Source: GO_Central
Positive regulation of protein phosphorylation Source: GO_Central
Regulation of cell migration Source: GO_Central
Signal transduction involved in regulation of gene expression Source: Ensembl

Cellular Location

Secreted

Involvement in disease

Trichomegaly (TCMGLY):
A morphologic trait characterized by unusually long eyelashes and mild hypertrichosis of eyebrows. It can be observed in association with corneal irritation, cataracts, and hereditary spherocytosis.

Zhang, G., Zheng, H., & Wang, L. (2022). miR‑491‑3p functions as a tumor suppressor in non‑small cell lung cancer by targeting fibroblast growth factor 5. Oncology Reports, 48(3), 1-12.

Hoang, S. H. (2022). Fibroblast Growth Factor 5 (FGF5) and Its Missense Mutant FGF5-Y174H Underlying Trichomegaly: A Molecular Dynamics Simulation Investigation. bioRxiv.

Shaffer, G. D., Ballif, B. C., Meurs, K., Shaffer, L. G., & Flores-Smith, H. (2021). Identification of a novel missense mutation in the fibroblast growth factor 5 gene associated with longhair in the Maine Coon Cat. Human Genetics, 140(11), 1517-1523.

Xu, Y., Liu, H., Pan, H., Wang, X., Zhang, Y., Yao, B., ... & Li, Z. (2020). CRISPR/Cas9-mediated disruption of fibroblast growth factor 5 in rabbits results in a systemic long hair phenotype by prolonging anagen. Genes, 11(3), 297.

Li, H., & Lipsett, K. A. (2019). The Association of Fibroblast Growth Factor 5 (FGF5), Fibroblast Growth Factor Receptor 1 (FGFR1), and Prolactin (PRL) with Hair Length in Scottish Highland Cattle. The FASEB Journal, 33(S1), 474-9.

McLean*, D., Cunningham, K., & Ricke, W. (2019). Mp68-20 establishing a negative feedback loop between fibroblast growth factor 5 and androgen receptor in prostate cancer. The Journal of Urology, 201(Supplement 4), e983-e983.

Zhou, Y., Yu, Q., Chu, Y., Zhu, X., Deng, J., Liu, Q., & Wang, Q. (2019). Downregulation of fibroblast growth factor 5 inhibits cell growth and invasion of human nonsmall‐cell lung cancer cells. Journal of Cellular Biochemistry, 120(5), 8238-8246.

Huang, Y., Wang, H., & Yang, Y. (2018). Expression of fibroblast growth factor 5 (FGF5) and its influence on survival of breast cancer patients. Medical science monitor: international medical journal of experimental and clinical research, 24, 3524.

Ren, Y., Jiao, X., & Zhang, L. (2018). Expression level of fibroblast growth factor 5 (FGF5) in the peripheral blood of primary hypertension and its clinical significance. Saudi journal of biological sciences, 25(3), 469-473.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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