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Rat Anti-FKBP3 (AA 2-224) Recombinant Antibody (CBXF-2643) (CBMAB-F3063-CQ)

This product is a rat antibody that recognizes FKBP3 (AA 2-224). The antibody CBXF-2643 can be used for immunoassay techniques such as: WB.
See all FKBP3 antibodies

Summary

Host Animal
Rat
Specificity
Human, Mouse, Rat
Clone
CBXF-2643
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
E. coli-derived recombinant human FKBP25, Ala2-Asp224, Accession # Q00688
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with trehalose
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 2-224

Target

Full Name
FK506 Binding Protein 3
Introduction
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.
Entrez Gene ID
Human2287
Mouse30795
Rat299104
UniProt ID
HumanQ00688
MouseQ62446
RatG3V6L9
Alternative Names
FK506 Binding Protein 3; Rapamycin-Selective 25 KDa Immunophilin; FK506 Binding Protein 3, 25kDa; 25 KDa FK506-Binding Protein; Immunophilin FKBP25; PPIase FKBP3; 25 KDa FKBP; Rotamase; FKBP-25; FKBP-3;
Function
FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins.
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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