Mouse Anti-FKBP3 Recombinant Antibody (2364C3) (CBMAB-F2373-CQ)

Name: Mouse Anti-FKBP3 Recombinant Antibody (2364C3)
SKU: CBMAB-F2373-CQ
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

2364C3

Antibody Isotype

IgG1

Application

Dot, IF, WB

Basic Information

Specificity

Human

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4, 1% BSA

Preservative

0.05% sodium azide

Concentration

0.1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Introduction

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.

Entrez Gene ID

2287

UniProt ID

Q00688

Alternative Names

FK506 Binding Protein 3; Rapamycin-Selective 25 KDa Immunophilin; FK506 Binding Protein 3, 25kDa; 25 KDa FK506-Binding Protein; Immunophilin FKBP25; PPIase FKBP3; 25 KDa FKBP; Rotamase; FKBP-25; FKBP-3;

Cellular Location

Nucleus

More Infomation

References

Yang, X., Zhao, X., Zhu, Y., Shen, Y., Wang, Y., Lu, P., ... & Zhu, H. (2021). FKBP3 induces human immunodeficiency virus type 1 latency by recruiting histone deacetylase 1/2 to the viral long terminal repeat. Mbio, 12(4), e00795-21.

Liu, P., Xie, X., Yang, A., Kong, Y., Allen-Gipson, D., Tian, Z., ... & Xie, X. (2020). Melatonin regulates breast cancer progression by the lnc010561/miR-30/FKBP3 Axis. Molecular Therapy-Nucleic Acids, 19, 765-774.

ZAN, L., LI, X., & CAI, X. (2020). Down-regulation of lncRNA SNHG6 inhibits breast cancer progression by targeting miR-30-5p/FKBP3 axis. Chinese Journal of Endocrine Surgery, 365-372.

Tong, J., Shen, Y., Chen, X., Wang, R., Hu, Y., Zhang, X., ... & Han, L. (2019). FKBP3 mediates oxaliplatin resistance in colorectal cancer cells by regulating HDAC2 expression. Oncology reports, 42(4), 1404-1412.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Rat Anti-FKBP3 (AA 2-224) Recombinant Antibody (CBXF-2643) (CAT#: CBMAB-F3063-CQ)

Mouse Anti-FKBP3 Recombinant Antibody (CBXF-3048) (CAT#: CBMAB-F3750-CQ)

Rat Anti-FKBP3 Recombinant Antibody (CBXF-0708) (CAT#: CBMAB-F2374-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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