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Mouse Anti-FMNL1 Recombinant Antibody (CBXF-0770) (CBMAB-F2403-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-0770
Antibody Isotype
IgG1
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 1% BSA
Preservative
0.05% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
formin-like 1
Introduction
This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. An alternative splice variant has been described but its full length sequence has not been determined.
Entrez Gene ID
752
UniProt ID
O95466
Alternative Names
Formin Like 1; CLL-Associated Antigen KW-13; Leukocyte Formin; C17orf1B; C17ORF1; FMNL; Formin-Like Protein 1;
Function
May play a role in the control of cell motility and survival of macrophages (By similarity).

Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape.
Biological Process
Actin filament severing Source: UniProtKB
Cell migration Source: GO_Central
Cortical actin cytoskeleton organization Source: UniProtKB
Regulation of cell shape Source: UniProtKB
Cellular Location
Cell membrane; Cytoplasm; Phagosome. Recruited to actin-rich phagosomes during phagocytosis. Translocates to the plasma membrane upon activation by RAC1 (By similarity).
Isoform 3: Cell cortex; Bleb. Colocalized with F-actin in bleb protrusions.
PTM
Myristoylation mediates membrane localization and blebbing.
More Infomation

Bruschi, M., Cavalli, A., Moll, S., Candiano, G., Scapozza, L., Patel, J. J., ... & Prunotto, M. (2022). Discovery of anti-Formin-like 1 protein (FMNL1) antibodies in membranous nephropathy and other glomerular diseases. Scientific Reports, 12(1), 13659.

Zhang, Q., Yang, H., Tang, C., Wang, Q., Ren, L., Jia, C., & Zou, H. (2021). FMNL1 promotes growth and metastasis of breast cancer by inhibiting BRCA1 via upregulation of HMGA1. Tropical Journal of Pharmaceutical Research, 20(8), 1559-1564.

Mansuri, N., Heuser, V. D., Birkman, E. M., Lintunen, M., Ålgars, A., Sundström, J., ... & Lehtinen, L. (2021). FHOD1 and FMNL1 formin proteins in intestinal gastric cancer: correlation with tumor-infiltrating T lymphocytes and molecular subtypes. Gastric Cancer, 24(6), 1254-1263.

Ma, G., Wang, Z., Liu, J., Fu, S., Zhang, L., Zheng, D., ... & Yue, Z. (2021). Quantitative proteomic analysis reveals sophisticated metabolic alteration and identifies FMNL1 as a prognostic marker in clear cell renal cell carcinoma. Journal of Cancer, 12(21), 6563.

Zhang, M. F., Li, Q. L., Yang, Y. F., Cao, Y., & Zhang, C. Z. (2020). FMNL1 exhibits pro-metastatic activity via CXCR2 in clear cell renal cell carcinoma. Frontiers in Oncology, 10, 564614.

Cui, F., Ji, Y., Wang, M., Gao, F., Li, Y., & Li, X. (2019). miR‐143 inhibits proliferation and metastasis of nasopharyngeal carcinoma cells via targeting FMNL1 based on clinical and radiologic findings. Journal of Cellular Biochemistry, 120(10), 16427-16434.

Yang, X. Y., Liao, J. J., & Xue, W. R. (2019). FMNL1 down-regulation suppresses bone metastasis through reducing TGF-β1 expression in non-small cell lung cancer (NSCLC). Biomedicine & Pharmacotherapy, 117, 109126.

Higa, N., Shinsato, Y., Kamil, M., Hirano, T., Takajo, T., Shimokawa, M., ... & Arita, K. (2019). Formin-like 1 (FMNL1) is associated with glioblastoma multiforme mesenchymal subtype and independently predicts poor prognosis. International journal of molecular sciences, 20(24), 6355.

Chen, W. H., Cai, M. Y., Zhang, J. X., Wang, F. W., Tang, L. Q., Liao, Y. J., ... & Xie, D. (2018). FMNL1 mediates nasopharyngeal carcinoma cell aggressiveness by epigenetically upregulating MTA1. Oncogene, 37(48), 6243-6258.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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