Mouse Anti-FMNL1 Recombinant Antibody (CBXF-3100) (CBMAB-F3796-CQ)

Name: Mouse Anti-FMNL1 Recombinant Antibody (CBXF-3100)
SKU: CBMAB-F3796-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-3100

Application

ELISA, WB

Immunogen

Partial recombinant corresponding to aa893-991 from human FMNL1 (NP_005883) with GST tag

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

formin-like 1

Introduction

This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. An alternative splice variant has been described but its full length sequence has not been determined.

Entrez Gene ID

752

UniProt ID

O95466

Alternative Names

Formin Like 1; CLL-Associated Antigen KW-13; Leukocyte Formin; C17orf1B; C17ORF1; FMNL; Formin-Like Protein 1;

Function

May play a role in the control of cell motility and survival of macrophages (By similarity).

Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape.

Biological Process

Actin filament severing Source: UniProtKB
Cell migration Source: GO_Central
Cortical actin cytoskeleton organization Source: UniProtKB
Regulation of cell shape Source: UniProtKB

Cellular Location

Cell membrane; Cytoplasm; Phagosome. Recruited to actin-rich phagosomes during phagocytosis. Translocates to the plasma membrane upon activation by RAC1 (By similarity).
Isoform 3: Cell cortex; Bleb. Colocalized with F-actin in bleb protrusions.

PTM

Myristoylation mediates membrane localization and blebbing.

Bruschi, M., Cavalli, A., Moll, S., Candiano, G., Scapozza, L., Patel, J. J., ... & Prunotto, M. (2022). Discovery of anti-Formin-like 1 protein (FMNL1) antibodies in membranous nephropathy and other glomerular diseases. Scientific Reports, 12(1), 13659.

Zhang, Q., Yang, H., Tang, C., Wang, Q., Ren, L., Jia, C., & Zou, H. (2021). FMNL1 promotes growth and metastasis of breast cancer by inhibiting BRCA1 via upregulation of HMGA1. Tropical Journal of Pharmaceutical Research, 20(8), 1559-1564.

Mansuri, N., Heuser, V. D., Birkman, E. M., Lintunen, M., Ålgars, A., Sundström, J., ... & Lehtinen, L. (2021). FHOD1 and FMNL1 formin proteins in intestinal gastric cancer: correlation with tumor-infiltrating T lymphocytes and molecular subtypes. Gastric Cancer, 24(6), 1254-1263.

Ma, G., Wang, Z., Liu, J., Fu, S., Zhang, L., Zheng, D., ... & Yue, Z. (2021). Quantitative proteomic analysis reveals sophisticated metabolic alteration and identifies FMNL1 as a prognostic marker in clear cell renal cell carcinoma. Journal of Cancer, 12(21), 6563.

Zhang, M. F., Li, Q. L., Yang, Y. F., Cao, Y., & Zhang, C. Z. (2020). FMNL1 exhibits pro-metastatic activity via CXCR2 in clear cell renal cell carcinoma. Frontiers in Oncology, 10, 564614.

Cui, F., Ji, Y., Wang, M., Gao, F., Li, Y., & Li, X. (2019). miR‐143 inhibits proliferation and metastasis of nasopharyngeal carcinoma cells via targeting FMNL1 based on clinical and radiologic findings. Journal of Cellular Biochemistry, 120(10), 16427-16434.

Yang, X. Y., Liao, J. J., & Xue, W. R. (2019). FMNL1 down-regulation suppresses bone metastasis through reducing TGF-β1 expression in non-small cell lung cancer (NSCLC). Biomedicine & Pharmacotherapy, 117, 109126.

Higa, N., Shinsato, Y., Kamil, M., Hirano, T., Takajo, T., Shimokawa, M., ... & Arita, K. (2019). Formin-like 1 (FMNL1) is associated with glioblastoma multiforme mesenchymal subtype and independently predicts poor prognosis. International journal of molecular sciences, 20(24), 6355.

Chen, W. H., Cai, M. Y., Zhang, J. X., Wang, F. W., Tang, L. Q., Liao, Y. J., ... & Xie, D. (2018). FMNL1 mediates nasopharyngeal carcinoma cell aggressiveness by epigenetically upregulating MTA1. Oncogene, 37(48), 6243-6258.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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