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Mouse Anti-FOSL1 Antibody (1E3) (CBMAB-0373-YC)

Provided herein are mouse monoclonal antibodies against Human FOSL1. The antibody clone 1E3 can be used for immunoassay techniques, such as IP, WB and MA.
See all FOSL1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1E3
Antibody Isotype
IgG1
Application
IP, WB, MA

Basic Information

Immunogen
Recombinant peptide
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
FOS like 1, AP-1 transcription factor subunit
Introduction
FOSL1 (FOS like 1, AP-1 transcription factor subunit) belongs to the Fos gene family. The leucine zipper proteins of Fos gene family that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.
Entrez Gene ID
8061
UniProt ID
P15407
Alternative Names
FOS Like Antigen 1; FOS-Like Antigen 1; Fra-1; FRA1; FOS-Like Antigen-1; FRA
Biological Process
Cellular defense response Source: ProtInc
Cellular response to extracellular stimulus Source: Ensembl
Chemotaxis Source: ProtInc
Female pregnancy Source: Ensembl
In utero embryonic development Source: Ensembl
Learning Source: Ensembl
Negative regulation of cell population proliferation Source: Ensembl
Placenta blood vessel development Source: Ensembl
Positive regulation of apoptotic process Source: Ensembl
Positive regulation of cell cycle Source: Ensembl
Positive regulation of cell population proliferation Source: ProtInc
Positive regulation of DNA-binding transcription factor activity Source: Ensembl
Positive regulation of DNA-templated transcription, initiation Source: CACAO
Positive regulation of pri-miRNA transcription by RNA polymerase II Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to cAMP Source: Ensembl
Response to corticosterone Source: Ensembl
Response to cytokine Source: Ensembl
Response to drug Source: Ensembl
Response to gravity Source: Ensembl
Response to hydrogen peroxide Source: Ensembl
Response to mechanical stimulus Source: Ensembl
Response to progesterone Source: Ensembl
Response to virus Source: ProtInc
Vitellogenesis Source: Ensembl
Cellular Location
Nucleus

Sobolev, V. V., Khashukoeva, A. Z., Evina, O. E., Geppe, N. A., Chebysheva, S. N., Korsunskaya, I. M., ... & Mezentsev, A. (2022). Role of the transcription factor FOSL1 in organ development and tumorigenesis. International journal of molecular sciences, 23(3), 1521.

Shetty, A., Tripathi, S. K., Junttila, S., Buchacher, T., Biradar, R., Bhosale, S. D., ... & Lahesmaa, R. (2022). A systematic comparison of FOSL1, FOSL2 and BATF-mediated transcriptional regulation during early human Th17 differentiation. Nucleic acids research, 50(9), 4938-4958.

Pecce, V., Verrienti, A., Fiscon, G., Sponziello, M., Conte, F., Abballe, L., ... & Paci, P. (2021). The role of FOSL1 in stem-like cell reprogramming processes. Scientific reports, 11(1), 1-11.

Vallejo, A., Erice, O., Entrialgo-Cadierno, R., Feliu, I., Guruceaga, E., Perugorria, M. J., ... & Vicent, S. (2021). FOSL1 promotes cholangiocarcinoma via transcriptional effectors that could be therapeutically targeted. Journal of hepatology, 75(2), 363-376.

Zhang, M., Hoyle, R. G., Ma, Z., Sun, B., Cai, W., Cai, H., ... & Li, J. (2021). FOSL1 promotes metastasis of head and neck squamous cell carcinoma through super-enhancer-driven transcription program. Molecular Therapy, 29(8), 2583-2600.

Dai, C., Rennhack, J. P., Arnoff, T. E., Thaker, M., Younger, S. T., Doench, J. G., ... & Hahn, W. C. (2021). SMAD4 represses FOSL1 expression and pancreatic cancer metastatic colonization. Cell reports, 36(4), 109443.

Nitkin, C. R., Xia, S., Menden, H., Yu, W., Xiong, M., Heruth, D. P., ... & Sampath, V. (2020). FOSL1 is a novel mediator of endotoxin/lipopolysaccharide-induced pulmonary angiogenic signaling. Scientific Reports, 10(1), 13143.

Chen, S., Youhong, T., Tan, Y., He, Y., Ban, Y., Cai, J., ... & Xiang, B. (2020). EGFR-PKM2 signaling promotes the metastatic potential of nasopharyngeal carcinoma through induction of FOSL1 and ANTXR2. Carcinogenesis, 41(6), 723-733.

He, S. W., Xu, C., Li, Y. Q., Li, Y. Q., Zhao, Y., Zhang, P. P., ... & Liu, N. (2020). AR-induced long non-coding RNA LINC01503 facilitates proliferation and metastasis via the SFPQ-FOSL1 axis in nasopharyngeal carcinoma. Oncogene, 39(34), 5616-5632.

Chen, X., Zhao, M., Huang, J., Li, Y., Wang, S., Harrington, C. A., ... & Dai, M. S. (2018). MicroRNA‐130a suppresses breast cancer cell migration and invasion by targeting FOSL1 and upregulating ZO‐1. Journal of cellular biochemistry, 119(6), 4945-4956.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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