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Rabbit Anti-FOSL1 Recombinant Antibody (CBXF-2071) (CBMAB-F2047-CQ)


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Summary

Host Animal
Rabbit
Specificity
Human, Monkey
Clone
CBXF-2071
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Specificity
Human, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
FOS like 1, AP-1 transcription factor subunit
Introduction
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
Human8061
Monkey106993191
UniProt ID
HumanP15407
MonkeyA0A2K5VU76
Alternative Names
FOS Like 1, AP-1 Transcription Factor Subunit; Fra-1; FRA1; FOS Like 1, AP-1 Trancription Factor Subunit; Fos-Related Antigen 1; FOS Like Antigen 1; FOS-Like Antigen-1; FRA;
Biological Process
Cellular defense response Source: ProtInc
Cellular response to extracellular stimulus Source: Ensembl
Chemotaxis Source: ProtInc
Female pregnancy Source: Ensembl
In utero embryonic development Source: Ensembl
Learning Source: Ensembl
Negative regulation of cell population proliferation Source: Ensembl
Placenta blood vessel development Source: Ensembl
Positive regulation of apoptotic process Source: Ensembl
Positive regulation of cell cycle Source: Ensembl
Positive regulation of cell population proliferation Source: ProtInc
Positive regulation of DNA-binding transcription factor activity Source: Ensembl
Positive regulation of DNA-templated transcription, initiation Source: CACAO
Positive regulation of pri-miRNA transcription by RNA polymerase II Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to cAMP Source: Ensembl
Response to corticosterone Source: Ensembl
Response to cytokine Source: Ensembl
Response to drug Source: Ensembl
Response to gravity Source: Ensembl
Response to hydrogen peroxide Source: Ensembl
Response to mechanical stimulus Source: Ensembl
Response to progesterone Source: Ensembl
Response to virus Source: ProtInc
Vitellogenesis Source: Ensembl
Cellular Location
Nucleus
More Infomation

Sobolev, V. V., Khashukoeva, A. Z., Evina, O. E., Geppe, N. A., Chebysheva, S. N., Korsunskaya, I. M., ... & Mezentsev, A. (2022). Role of the transcription factor FOSL1 in organ development and tumorigenesis. International journal of molecular sciences, 23(3), 1521.

Shetty, A., Tripathi, S. K., Junttila, S., Buchacher, T., Biradar, R., Bhosale, S. D., ... & Lahesmaa, R. (2022). A systematic comparison of FOSL1, FOSL2 and BATF-mediated transcriptional regulation during early human Th17 differentiation. Nucleic acids research, 50(9), 4938-4958.

Pecce, V., Verrienti, A., Fiscon, G., Sponziello, M., Conte, F., Abballe, L., ... & Paci, P. (2021). The role of FOSL1 in stem-like cell reprogramming processes. Scientific reports, 11(1), 1-11.

Vallejo, A., Erice, O., Entrialgo-Cadierno, R., Feliu, I., Guruceaga, E., Perugorria, M. J., ... & Vicent, S. (2021). FOSL1 promotes cholangiocarcinoma via transcriptional effectors that could be therapeutically targeted. Journal of hepatology, 75(2), 363-376.

Zhang, M., Hoyle, R. G., Ma, Z., Sun, B., Cai, W., Cai, H., ... & Li, J. (2021). FOSL1 promotes metastasis of head and neck squamous cell carcinoma through super-enhancer-driven transcription program. Molecular Therapy, 29(8), 2583-2600.

Dai, C., Rennhack, J. P., Arnoff, T. E., Thaker, M., Younger, S. T., Doench, J. G., ... & Hahn, W. C. (2021). SMAD4 represses FOSL1 expression and pancreatic cancer metastatic colonization. Cell reports, 36(4), 109443.

Nitkin, C. R., Xia, S., Menden, H., Yu, W., Xiong, M., Heruth, D. P., ... & Sampath, V. (2020). FOSL1 is a novel mediator of endotoxin/lipopolysaccharide-induced pulmonary angiogenic signaling. Scientific Reports, 10(1), 13143.

Chen, S., Youhong, T., Tan, Y., He, Y., Ban, Y., Cai, J., ... & Xiang, B. (2020). EGFR-PKM2 signaling promotes the metastatic potential of nasopharyngeal carcinoma through induction of FOSL1 and ANTXR2. Carcinogenesis, 41(6), 723-733.

He, S. W., Xu, C., Li, Y. Q., Li, Y. Q., Zhao, Y., Zhang, P. P., ... & Liu, N. (2020). AR-induced long non-coding RNA LINC01503 facilitates proliferation and metastasis via the SFPQ-FOSL1 axis in nasopharyngeal carcinoma. Oncogene, 39(34), 5616-5632.

Chen, X., Zhao, M., Huang, J., Li, Y., Wang, S., Harrington, C. A., ... & Dai, M. S. (2018). MicroRNA‐130a suppresses breast cancer cell migration and invasion by targeting FOSL1 and upregulating ZO‐1. Journal of cellular biochemistry, 119(6), 4945-4956.

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For research use only. Not intended for any clinical use.

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