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Mouse Anti-GRM7 Recombinant Antibody (CBT2551) (V2LY-0625-LY764)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT2551
Antibody Isotype
IgG1
Application
ICC, FC

Basic Information

Immunogen
Purified recombinant fragment of human GRM7 (AA: 454-590) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
ICC1:200-1:1,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
glutamate metabotropic receptor 7
Entrez Gene ID
2917
UniProt ID
Q14831
Function
G-protein coupled receptor activated by glutamate that regulates axon outgrowth through the MAPK-cAMP-PKA signaling pathway during neuronal development (PubMed:33500274).

Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase that it inhibits (PubMed:9473604).
Biological Process
Adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway Source: UniProtKB
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: UniProtKB
Axon development Source: UniProtKB
Chemical synaptic transmission Source: UniProtKB
Glycosylation Source: UniProtKB
G protein-coupled glutamate receptor signaling pathway Source: GO_Central
Negative regulation of glutamate secretion Source: UniProtKB
Regulation of synaptic transmission, glutamatergic Source: GO_Central
Sensory perception of sound Source: UniProtKB
Cellular Location
Cell membrane
Involvement in disease
Neurodevelopmental disorder with seizures, hypotonia, and brain imaging abnormalities (NEDSHBA):
An autosomal recessive neurodevelopmental disorder characterized by global developmental delay, hypotonia, severe to profound intellectual disability, early-onset epilepsy, and microcephaly. Neuroimaging shows cerebral atrophy, thin corpus callosum and hypomyelination in a majority of cases. Death in childhood may occur.
Topology
Extracellular: 35-590
Helical: 591-615
Cytoplasmic: 616-627
Helical: 628-648
Extracellular: 649-654
Helical: 655-675
Cytoplasmic: 676-702
Helical: 703-723
Extracellular: 724-753
Helical: 754-775
Cytoplasmic: 776-788
Helical: 789-810
Extracellular: 811-825
Helical: 826-850
Cytoplasmic: 851-915
PTM
N-glycosylated.
More Infomation

Chaumette, B., Sengupta, S. M., Lepage, M., Malla, A., Iyer, S. N., Kebir, O., ... & ICAAR study group. (2022). A polymorphism in the glutamate metabotropic receptor 7 is associated with cognitive deficits in the early phases of psychosis. Schizophrenia Research, 249, 56-62.

Jdila, M. B., Mignon-Ravix, C., Ncir, S. B., Kammoun, F., Fakhfakh, F., Villard, L., & Triki, C. (2021). A large consanguineous family with a homozygous Metabotropic Glutamate Receptor 7 (mGlu7) variant and developmental epileptic encephalopathy: Effect on protein structure and ligand affinity. Orphanet journal of rare diseases, 16(1), 1-12.

Fisher, N. M., AlHashim, A., Buch, A. B., Badivuku, H., Samman, M. M., Weiss, K. M., ... & Niswender, C. M. (2021). A GRM7 mutation associated with developmental delay reduces mGlu7 expression and produces neurological phenotypes. JCI insight, 6(4).

Safari, M. R., Beirami, A. D., Khazaie, M., Komaki, A., Noroozi, R., Ghafouri-Fard, S., & Taheri, M. (2020). GRM7 polymorphisms are not associated with ischemic stroke in Iranian population. Nucleosides, Nucleotides & Nucleic Acids, 39(5), 792-798.

Liang, W., Yu, H., Su, Y., Lu, T., Yan, H., Yue, W., & Zhang, D. (2020). Variants of GRM7 as risk factor and response to antipsychotic therapy in schizophrenia. Translational Psychiatry, 10(1), 83.

Noroozi, R., Taheri, M., Omrani, M. D., & Ghafouri-Fard, S. (2019). Glutamate receptor metabotropic 7 (GRM7) gene polymorphisms in mood disorders and attention deficit hyperactive disorder. Neurochemistry International, 129, 104483.

Mazdeh, M., Noroozi, R., Komaki, A., Azari, I., Ghafouri-Fard, S., & Taheri, M. (2019). A single nucleotide polymorphism in the metabotropic glutamate receptor 7 gene is associated with multiple sclerosis in Iranian population. Multiple sclerosis and related disorders, 28, 189-192.

Sun, Q., Yuan, F., Yuan, R., Ren, D., Zhu, Y., Bi, Y., ... & He, G. (2019). GRIK4 and GRM7 gene may be potential indicator of venlafaxine treatment reponses in Chinese of Han ethnicity. Medicine, 98(19).

Fisher, N. M., Seto, M., Lindsley, C. W., & Niswender, C. M. (2018). Metabotropic glutamate receptor 7: a new therapeutic target in neurodevelopmental disorders. Frontiers in molecular neuroscience, 11, 387.

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For research use only. Not intended for any clinical use.

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