Mouse Anti-HOXB13 Recombinant Antibody (CBFYH-1763) (CBMAB-H0232-FY)

Name: Mouse Anti-HOXB13 Recombinant Antibody (CBFYH-1763)
SKU: CBMAB-H0232-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYH-1763

Application

WB, FC, IF

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

0.7 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Homeobox B13

Introduction

This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region.

Entrez Gene ID

10481

UniProt ID

Q92826

Alternative Names

Homeobox B13; Homeobox Protein Hox-B13; Homeo Box B13; PSGD

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA (PubMed:28473536).

Biological Process

Angiogenesis Source: UniProtKB
Epidermis development Source: ProtInc
Epithelial cell maturation involved in prostate gland development Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: Ensembl
Regulation of growth Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to testosterone Source: Ensembl
Response to wounding Source: ProtInc

Cellular Location

Nucleus

Involvement in disease

Prostate cancer (PC):
A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.

Lu, X., Fong, K. W., Gritsina, G., Wang, F., Baca, S. C., Brea, L. T., ... & Yu, J. (2022). HOXB13 suppresses de novo lipogenesis through HDAC3-mediated epigenetic reprogramming in prostate cancer. Nature genetics, 54(5), 670-683.

Guo, C., Chu, H., Gong, Z., Zhang, B., Li, C., Chen, J., & Huang, L. (2021). HOXB13 promotes gastric cancer cell migration and invasion via IGF-1R upregulation and subsequent activation of PI3K/AKT/mTOR signaling pathway. Life Sciences, 278, 119522.

Zhang, L., Wan, Y., Zhang, Z., Jiang, Y., Lang, J., Cheng, W., & Zhu, L. (2021). FTO demethylates m6A modifications in HOXB13 mRNA and promotes endometrial cancer metastasis by activating the WNT signalling pathway. RNA biology, 18(9), 1265-1278.

Nguyen, N. U. N., Canseco, D. C., Xiao, F., Nakada, Y., Li, S., Lam, N. T., ... & Sadek, H. A. (2020). A calcineurin–Hoxb13 axis regulates growth mode of mammalian cardiomyocytes. Nature, 582(7811), 271-276.

Wang, X., Wang, R., Wu, Z., & Bai, P. (2019). Circular RNA ITCH suppressed prostate cancer progression by increasing HOXB13 expression via spongy miR-17-5p. Cancer cell international, 19(1), 1-11.

Johng, D., Torga, G., Ewing, C. M., Jin, K., Norris, J. D., McDonnell, D. P., & Isaacs, W. B. (2019). HOXB13 interaction with MEIS1 modifies proliferation and gene expression in prostate cancer. The Prostate, 79(4), 414-424.

Zhan, J., Wang, P., Li, S., Song, J., He, H., Wang, Y., ... & Zhang, H. (2019). HOXB13 networking with ABCG1/EZH2/Slug mediates metastasis and confers resistance to cisplatin in lung adenocarcinoma patients. Theranostics, 9(7), 2084.

Li, R. C., Ke, S., Meng, F. K., Lu, J., Zou, X. J., He, Z. G., ... & Fang, M. H. (2018). CiRS-7 promotes growth and metastasis of esophageal squamous cell carcinoma via regulation of miR-7/HOXB13. Cell death & disease, 9(8), 838.

Chen, Z., Wu, D., Thomas-Ahner, J. M., Lu, C., Zhao, P., Zhang, Q., ... & Wang, Q. (2018). Diverse AR-V7 cistromes in castration-resistant prostate cancer are governed by HoxB13. Proceedings of the National Academy of Sciences, 115(26), 6810-6815.

Liu, B., Wang, T., Wang, H., Zhang, L., Xu, F., Fang, R., ... & Ye, L. (2018). Oncoprotein HBXIP enhances HOXB13 acetylation and co-activates HOXB13 to confer tamoxifen resistance in breast cancer. Journal of Hematology & Oncology, 11(1), 1-18.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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