HOXB13

This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region. [provided by RefSeq, Jul 2008]

Full Name

Homeobox B13

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA (PubMed:28473536).

Biological Process

Angiogenesis Source: UniProtKB
Epidermis development Source: ProtInc
Epithelial cell maturation involved in prostate gland development Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: Ensembl
Regulation of growth Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to testosterone Source: Ensembl
Response to wounding Source: ProtInc

Cellular Location

Nucleus

Involvement in disease

Prostate cancer (PC):
A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.