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Rabbit Anti-HOXB13 Recombinant Antibody (D7N8O) (CBMAB-CP1059-LY)

The product is antibody recognizes HOXB13. The antibody D7N8O immunoassay techniques such as: WB,IP,IHC-P.
See all HOXB13 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Monkey
Clone
D7N8O
Antibody Isotype
IgG
Application
WB, IP, IHC-P

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly11 of human HOXB13 protein.
Specificity
Human, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Homeobox B13
Introduction
This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human10481
Monkey697572
UniProt ID
HumanQ92826
MonkeyA0A5F8AA94
Alternative Names
Homeobox B13; Homeobox Protein Hox-B13; Homeo Box B13; PSGD;
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA (PubMed:28473536).
Biological Process
Angiogenesis Source: UniProtKB
Epidermis development Source: ProtInc
Epithelial cell maturation involved in prostate gland development Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: Ensembl
Regulation of growth Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to testosterone Source: Ensembl
Response to wounding Source: ProtInc
Cellular Location
Nucleus
Involvement in disease
Prostate cancer (PC):
A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.

Lu, X., Fong, K. W., Gritsina, G., Wang, F., Baca, S. C., Brea, L. T., ... & Yu, J. (2022). HOXB13 suppresses de novo lipogenesis through HDAC3-mediated epigenetic reprogramming in prostate cancer. Nature genetics, 54(5), 670-683.

Guo, C., Chu, H., Gong, Z., Zhang, B., Li, C., Chen, J., & Huang, L. (2021). HOXB13 promotes gastric cancer cell migration and invasion via IGF-1R upregulation and subsequent activation of PI3K/AKT/mTOR signaling pathway. Life Sciences, 278, 119522.

Zhang, L., Wan, Y., Zhang, Z., Jiang, Y., Lang, J., Cheng, W., & Zhu, L. (2021). FTO demethylates m6A modifications in HOXB13 mRNA and promotes endometrial cancer metastasis by activating the WNT signalling pathway. RNA biology, 18(9), 1265-1278.

Nguyen, N. U. N., Canseco, D. C., Xiao, F., Nakada, Y., Li, S., Lam, N. T., ... & Sadek, H. A. (2020). A calcineurin–Hoxb13 axis regulates growth mode of mammalian cardiomyocytes. Nature, 582(7811), 271-276.

Wang, X., Wang, R., Wu, Z., & Bai, P. (2019). Circular RNA ITCH suppressed prostate cancer progression by increasing HOXB13 expression via spongy miR-17-5p. Cancer cell international, 19(1), 1-11.

Johng, D., Torga, G., Ewing, C. M., Jin, K., Norris, J. D., McDonnell, D. P., & Isaacs, W. B. (2019). HOXB13 interaction with MEIS1 modifies proliferation and gene expression in prostate cancer. The Prostate, 79(4), 414-424.

Zhan, J., Wang, P., Li, S., Song, J., He, H., Wang, Y., ... & Zhang, H. (2019). HOXB13 networking with ABCG1/EZH2/Slug mediates metastasis and confers resistance to cisplatin in lung adenocarcinoma patients. Theranostics, 9(7), 2084.

Li, R. C., Ke, S., Meng, F. K., Lu, J., Zou, X. J., He, Z. G., ... & Fang, M. H. (2018). CiRS-7 promotes growth and metastasis of esophageal squamous cell carcinoma via regulation of miR-7/HOXB13. Cell death & disease, 9(8), 838.

Chen, Z., Wu, D., Thomas-Ahner, J. M., Lu, C., Zhao, P., Zhang, Q., ... & Wang, Q. (2018). Diverse AR-V7 cistromes in castration-resistant prostate cancer are governed by HoxB13. Proceedings of the National Academy of Sciences, 115(26), 6810-6815.

Liu, B., Wang, T., Wang, H., Zhang, L., Xu, F., Fang, R., ... & Ye, L. (2018). Oncoprotein HBXIP enhances HOXB13 acetylation and co-activates HOXB13 to confer tamoxifen resistance in breast cancer. Journal of Hematology & Oncology, 11(1), 1-18.

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For research use only. Not intended for any clinical use.

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