Mouse Anti-KRT75 Recombinant Antibody (3F9) (CBMAB-K1992-LY)

Name: Mouse Anti-KRT75 Recombinant Antibody (3F9)
SKU: CBMAB-K1992-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

3F9

Application

ELISA, WB

Immunogen

KRT75 (NP_004684, 141 a.a. ~ 240 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: TIQRVRAEER EQIKTLNNKF ASFIDKVRFL EQQNKVLETK WALLQEQGSR TVRQNLEPLF DSYTSELRRQ LESITTERGR LEAELRNMQD VVEDFKVRYE

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

keratin 75

Introduction

This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. This gene is expressed in the companion layer, upper germinative matrix region of the hair follicle, and medulla of the hair shaft. The encoded protein plays an essential role in hair and nail formation. Variations in this gene have been associated with the hair disorders pseudofolliculitis barbae (PFB) and loose anagen hair syndrome (LAHS). [provided by RefSeq, Oct 2008]

Entrez Gene ID

9119

UniProt ID

O95678

Alternative Names

Keratin 75; Keratin-6 Hair Follicle; Type II Keratin-K6hf; Type-II Keratin Kb18; Keratin 75; Type II; Cytokeratin-75; CK-75; HK6hf; K6HF;

Function

Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle.

Biological Process

Hematopoietic progenitor cell differentiationIEA:Ensembl

Cellular Location

Cytosol
Extracellular exosome
Intermediate filament
Keratin filament

Involvement in disease

Loose anagen hair syndrome (LAHS):
In LAHS, anagen hairs are easily pulled from the scalp. The hair is relatively sparse and does not grow long. Hair of fair color and hair shafts of reduced caliber, and an early age of onset are features. Usually the hairs are not fragile and there are no areas of breakage.

Deshmukh, R., Vasquez, B., Bhogadi, L., Gabe, C. M., Lukashova, L., Verdelis, K., ... & Beniash, E. (2022). Elucidating the role of keratin 75 in enamel using Krt75tm1Der knock-in mouse model. Frontiers in Physiology, 13, 2664.

Cai, C., Huang, B., Qu, K., Zhang, J., & Lei, C. (2021). A novel missense mutation within KRT75 gene strongly affects heat stress in Chinese cattle. Gene, 768, 145294.

Deshmukh, R. (2021). Role of Keratin-75 in enamel (Doctoral dissertation, University of Pittsburgh).

Mottaghitalab, F., Lanjanian, H., & Masoudi-Nejad, A. (2021). Revealing transcriptional and post-transcriptional regulatory mechanisms of γ-glutamyl transferase and keratin isoforms as novel cooperative biomarkers in low-grade glioma and glioblastoma multiforme. Genomics, 113(4), 2623-2633.

Morgan, H. J., Benketah, A., Olivero, C., Rees, E., Ziaj, S., Mukhtar, A., ... & Patel, G. K. (2020). Hair follicle differentiation‐specific keratin expression in human basal cell carcinoma. Clinical and Experimental Dermatology, 45(4), 417-425.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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