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Mouse Anti-KRT75 Recombinant Antibody (5F224) (CBMAB-K0217-LY)

This product is antibody recognizes KRT75. The antibody 5F224 immunoassay techniques such as: IF, IHC, WB.
See all KRT75 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
5F224
Antibody Isotype
IgG2a
Application
IF, IHC, WB

Basic Information

Immunogen
Cytoskeletal proteins from cultured human MCF-7 cells
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
keratin 75
Introduction
This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. This gene is expressed in the companion layer, upper germinative matrix region of the hair follicle, and medulla of the hair shaft. The encoded protein plays an essential role in hair and nail formation. Variations in this gene have been associated with the hair disorders pseudofolliculitis barbae (PFB) and loose anagen hair syndrome (LAHS). [provided by RefSeq, Oct 2008]
Entrez Gene ID
9119
UniProt ID
O95678
Alternative Names
Keratin 75; Keratin-6 Hair Follicle; Type II Keratin-K6hf; Type-II Keratin Kb18; Keratin 75; Type II; Cytokeratin-75; CK-75; HK6hf; K6HF;
Function
Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle.
Biological Process
Hematopoietic progenitor cell differentiationIEA:Ensembl
Cellular Location
Cytosol
Extracellular exosome
Intermediate filament
Keratin filament
Involvement in disease
Loose anagen hair syndrome (LAHS):
In LAHS, anagen hairs are easily pulled from the scalp. The hair is relatively sparse and does not grow long. Hair of fair color and hair shafts of reduced caliber, and an early age of onset are features. Usually the hairs are not fragile and there are no areas of breakage.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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