KRT75

This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. This gene is expressed in the companion layer, upper germinative matrix region of the hair follicle, and medulla of the hair shaft. The encoded protein plays an essential role in hair and nail formation. Variations in this gene have been associated with the hair disorders pseudofolliculitis barbae (PFB) and loose anagen hair syndrome (LAHS). [provided by RefSeq]
Full Name
keratin 75
Function
Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle.
Biological Process
Hematopoietic progenitor cell differentiationIEA:Ensembl
Cellular Location
Cytosol
Extracellular exosome
Intermediate filament
Keratin filament
Involvement in disease
Loose anagen hair syndrome (LAHS):
In LAHS, anagen hairs are easily pulled from the scalp. The hair is relatively sparse and does not grow long. Hair of fair color and hair shafts of reduced caliber, and an early age of onset are features. Usually the hairs are not fragile and there are no areas of breakage.
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Anti-KRT75 antibodies

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Mouse Anti-KRT75 Recombinant Antibody (B311-1) (CBMAB-K1995-LY)

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Target: KRT75
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: B311-1
Application*: P
Datasheet SDS

Rat Anti-KRT75 Recombinant Antibody (8A3) (CBMAB-K1993-LY)

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Target: KRT75
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: 8A3
Application*: P
Datasheet SDS

Mouse Anti-KRT75 Recombinant Antibody (3F9) (CBMAB-K1992-LY)

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Target: KRT75
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3F9
Application*: E, WB
Datasheet SDS

Mouse Anti-KRT75 Recombinant Antibody (5F224) (CBMAB-K0217-LY)

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Target: KRT75
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 5F224
Application*: IF, IH, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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